Senolysis by glutaminolysis inhibition ameliorates various age-associated disorders.

Adipose Tissue / enzymology Aging / genetics Ammonia / metabolism Animals Cell Survival Cellular Senescence / genetics Genes, Essential Glutaminase / genetics Humans Hydrogen-Ion Concentration Lung / enzymology Male Mice Mice, Inbred C57BL Skin / enzymology

Journal

Science (New York, N.Y.)
ISSN: 1095-9203
Titre abrégé: Science
Pays: United States
ID NLM: 0404511

Informations de publication

Date de publication:
15 01 2021
Historique:
received: 05 03 2020
revised: 14 09 2020
accepted: 13 11 2020
entrez: 15 1 2021
pubmed: 16 1 2021
medline: 11 2 2021
Statut: ppublish

Résumé

Removal of senescent cells (senolysis) has been proposed to be beneficial for improving age-associated pathologies, but the molecular pathways for such senolytic activity have not yet emerged. Here, we identified glutaminase 1 (

Identifiants

DOI: 10.1126/science.abb5916 PMID: 33446552
pubmed: 33446552
pii: 371/6526/265
doi: 10.1126/science.abb5916
doi:

Substances chimiques

Ammonia 7664-41-7
GLS protein, human EC 3.5.1.2
Glutaminase EC 3.5.1.2

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

265-270

Commentaires et corrections

Type : CommentIn

Informations de copyright

Copyright © 2021 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works.

Auteurs

Yoshikazu Johmura (Y)

Division of Cancer Cell Biology, Institute of Medical Science, The University of Tokyo, 4-6-1 Shirokanedai, Minato-ku, Tokyo 108-8639, Japan. mkt-naka@ims.u-tokyo.ac.jp johmuray@ims.u-tokyo.ac.jp.
ORCID: 0000-0002-6812-9607

Takehiro Yamanaka (T)

Division of Cancer Cell Biology, Institute of Medical Science, The University of Tokyo, 4-6-1 Shirokanedai, Minato-ku, Tokyo 108-8639, Japan.
ORCID: 0000-0003-3714-2697

Satotaka Omori (S)

Division of Cancer Cell Biology, Institute of Medical Science, The University of Tokyo, 4-6-1 Shirokanedai, Minato-ku, Tokyo 108-8639, Japan.
ORCID: 0000-0002-0423-7289

Teh-Wei Wang (TW)

Division of Cancer Cell Biology, Institute of Medical Science, The University of Tokyo, 4-6-1 Shirokanedai, Minato-ku, Tokyo 108-8639, Japan.
ORCID: 0000-0001-9874-2392

Yuki Sugiura (Y)

Department of Biochemistry, Keio University School of Medicine, 35 Shinanomachi, Shinjyuku-ku, Tokyo 160-8582, Japan.
ORCID: 0000-0002-6983-8958

Masaki Matsumoto (M)

Department of Molecular and Cellular Biology, Medical Institute of Bioregulation, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582, Japan.
ORCID: 0000-0002-6987-0288

Narumi Suzuki (N)

Division of Cancer Cell Biology, Institute of Medical Science, The University of Tokyo, 4-6-1 Shirokanedai, Minato-ku, Tokyo 108-8639, Japan.
ORCID: 0000-0001-6024-9949

Soichiro Kumamoto (S)

Division of Cancer Cell Biology, Institute of Medical Science, The University of Tokyo, 4-6-1 Shirokanedai, Minato-ku, Tokyo 108-8639, Japan.
ORCID: 0000-0002-3492-117X

Kiyoshi Yamaguchi (K)

Clinical Genome Research, Institute of Medical Science, The University of Tokyo, 4-6-1 Shirokanedai, Minato-ku, Tokyo 108-8639, Japan.
ORCID: 0000-0003-2113-4369

Seira Hatakeyama (S)

Clinical Genome Research, Institute of Medical Science, The University of Tokyo, 4-6-1 Shirokanedai, Minato-ku, Tokyo 108-8639, Japan.
ORCID: 0000-0002-5726-3317

Tomoyo Takami (T)

Department of Molecular and Cellular Biology, Medical Institute of Bioregulation, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582, Japan.
ORCID: 0000-0002-6974-8119

Rui Yamaguchi (R)

Human Genome Center, Institute of Medical Science, The University of Tokyo, 4-6-1 Shirokanedai, Minato-ku, Tokyo 108-8639, Japan.
ORCID: 0000-0003-1224-227X

Eigo Shimizu (E)

Human Genome Center, Institute of Medical Science, The University of Tokyo, 4-6-1 Shirokanedai, Minato-ku, Tokyo 108-8639, Japan.
ORCID: 0000-0002-2486-2321

Kazutaka Ikeda (K)

RIKEN Center for Integrative Medical Sciences, Suehiro-cho, Tsurumi-ku, Yokohama, Kanagawa 230-0045, Japan.
ORCID: 0000-0001-9247-4593

Nobuyuki Okahashi (N)

RIKEN Center for Integrative Medical Sciences, Suehiro-cho, Tsurumi-ku, Yokohama, Kanagawa 230-0045, Japan.
ORCID: 0000-0001-9582-355X

Ryuta Mikawa (R)

Research Institute, National Center for Geriatrics and Gerontology, 7-430 Morioka-cho, Obu, Aichi 474-8511, Japan.
ORCID: 0000-0003-0006-9051

Makoto Suematsu (M)

Department of Biochemistry, Keio University School of Medicine, 35 Shinanomachi, Shinjyuku-ku, Tokyo 160-8582, Japan.
ORCID: 0000-0002-7165-6336

Makoto Arita (M)

RIKEN Center for Integrative Medical Sciences, Suehiro-cho, Tsurumi-ku, Yokohama, Kanagawa 230-0045, Japan.
Division of Physiological Chemistry and Metabolism, Graduate School of Pharmaceutical Sciences, Keio University, Shibakoen, Minato-ku, Tokyo 105-0011, Japan.
ORCID: 0000-0001-9902-0463

Masataka Sugimoto (M)

Research Institute, National Center for Geriatrics and Gerontology, 7-430 Morioka-cho, Obu, Aichi 474-8511, Japan.
ORCID: 0000-0001-8737-8097

Keiichi I Nakayama (KI)

Department of Molecular and Cellular Biology, Medical Institute of Bioregulation, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582, Japan.
ORCID: 0000-0002-7185-1529

Yoichi Furukawa (Y)

Clinical Genome Research, Institute of Medical Science, The University of Tokyo, 4-6-1 Shirokanedai, Minato-ku, Tokyo 108-8639, Japan.
ORCID: 0000-0003-0462-8631

Seiya Imoto (S)

Health Intelligence Center, Institute of Medical Science, The University of Tokyo, 4-6-1 Shirokanedai, Minato-ku, Tokyo 108-8639, Japan.
ORCID: 0000-0002-2989-308X

Makoto Nakanishi (M)

Division of Cancer Cell Biology, Institute of Medical Science, The University of Tokyo, 4-6-1 Shirokanedai, Minato-ku, Tokyo 108-8639, Japan. mkt-naka@ims.u-tokyo.ac.jp johmuray@ims.u-tokyo.ac.jp.
ORCID: 0000-0002-6707-3584

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Classifications MeSH

questionsmedicales.fr › Tissus › Tissu conjonctif › Tissu adipeux › Senolysis by glutaminolysis inhibition...
questionsmedicales.fr › Phénomènes physiologiques › Croissance et développement › Vieillissement › Senolysis by glutaminolysis inhibition...
questionsmedicales.fr › Produits chimiques inorganiques › Composés de l'azote › Ammoniac › Senolysis by glutaminolysis inhibition...
questionsmedicales.fr › Eucaryotes › Animaux › Senolysis by glutaminolysis inhibition...
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Survie cellulaire › Senolysis by glutaminolysis inhibition...
questionsmedicales.fr › Phénomènes physiologiques › Croissance et développement › Vieillissement › Vieillissement de la cellule › Senolysis by glutaminolysis inhibition...
questionsmedicales.fr › Phénomènes génétiques › Structures génétiques › Génome › Composants de génome › Gènes › Gènes essentiels › Senolysis by glutaminolysis inhibition...
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Hydrolases › Amidohydrolases › Glutaminase › Senolysis by glutaminolysis inhibition...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Senolysis by glutaminolysis inhibition...
questionsmedicales.fr › Phénomènes chimiques › Concentration en ions d'hydrogène › Senolysis by glutaminolysis inhibition...
questionsmedicales.fr › Appareil respiratoire › Poumon › Senolysis by glutaminolysis inhibition...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Senolysis by glutaminolysis inhibition...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Lignées consanguines de souris › Souris de lignée C57BL › Senolysis by glutaminolysis inhibition...
questionsmedicales.fr › Système tégumentaire › Peau › Senolysis by glutaminolysis inhibition...