Vasoactive intestinal polypeptide plasma levels associated with affective symptoms and brain structure and function in healthy females.

Adult Anxiety / blood Brain / diagnostic imaging Depression / blood Female Humans Magnetic Resonance Imaging Middle Aged Vasoactive Intestinal Peptide / blood

Journal

Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288

Informations de publication

Date de publication:
14 01 2021
Historique:
received: 03 09 2020
accepted: 21 12 2020
entrez: 15 1 2021
pubmed: 16 1 2021
medline: 12 8 2021
Statut: epublish

Résumé

Vasoactive intestinal polypeptide (VIP) is a neuroendocrine peptide distributed throughout the human body, including the CNS, where it is particularly abundant in brain regions associated with anxiety and depression. Based on earlier studies indicating that peripheral VIP may cross through the blood-brain barrier, we hypothesized plasma VIP levels to be associated with symptoms of anxiety and depression, as well as brain volume and resting-state functional connectivity in the amygdala, hippocampus, parahippocampus, and orbitofrontal cortex. Plasma VIP concentrations and anxiety/depression symptoms were measured in 37 healthy females. Functional and structural magnetic resonance imaging were used to evaluate functional connectivity and brain volume respectively, and their associations with VIP concentrations within brain regions associated with anxiety and depression. Negative correlations were found between VIP levels and symptoms of anxiety (r = - 0.44, p = 0.002) and depression (r = - 0.50, p = 0.001). Functional connectivity demonstrated significant VIP-dependent positive associations between the amygdala seed region with both the right parahippocampus (t

Identifiants

DOI: 10.1038/s41598-020-80873-2 PMID: 33446759 PMC: PMC7809454
pubmed: 33446759
doi: 10.1038/s41598-020-80873-2
pii: 10.1038/s41598-020-80873-2
pmc: PMC7809454
doi:

Substances chimiques

Vasoactive Intestinal Peptide 37221-79-7

Types de publication

Clinical Trial Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

1406

Références

Peptides. 1993 Sep-Oct;14(5):1067-71
pubmed: 8284258
Hum Brain Mapp. 2015 Dec;36(12):4819-30
pubmed: 26769550
Nat Neurosci. 2019 Nov;22(11):1834-1843
pubmed: 31636447
Neurol Res. 2017 Jan;39(1):65-72
pubmed: 27786097
Neuron. 2019 Mar 20;101(6):1150-1165.e8
pubmed: 30713030
Front Psychiatry. 2019 Oct 01;10:703
pubmed: 31632306
Neuroimage. 2003 Dec;20(4):2091-9
pubmed: 14683713
Annu Rev Neurosci. 1992;15:353-75
pubmed: 1575447
Nature. 2013 Nov 28;503(7477):521-4
pubmed: 24097352
Neuron. 2016 Jul 20;91(2):260-92
pubmed: 27477017
Brain Res Brain Res Rev. 2004 May;45(2):96-103
pubmed: 15145620
Eur J Neurosci. 2009 Feb;29(4):823-32
pubmed: 19200075
Dig Dis Sci. 2012 Feb;57(2):303-10
pubmed: 22143367
Pharmacol Toxicol. 1993 Jun;72(6):354-63
pubmed: 8103215
Front Psychol. 2017 Aug 24;8:1454
pubmed: 28883804
Neuroimage. 2000 Jun;11(6 Pt 1):805-21
pubmed: 10860804
Dig Dis Sci. 1987 Apr;32(4):369-76
pubmed: 2435473
Int J Mol Sci. 2019 Dec 20;21(1):
pubmed: 31861827
Biol Psychiatry. 2018 May 15;83(10):800-809
pubmed: 29174478
J Neurosci. 2015 Apr 15;35(15):6020-7
pubmed: 25878275
Biol Psychiatry. 2019 Nov 1;86(9):669-681
pubmed: 31326084
Front Syst Neurosci. 2016 Feb 22;10:12
pubmed: 26941618
Nat Rev Neurosci. 2015 Jun;16(6):317-31
pubmed: 25991441
Neuropsychobiology. 2020;79(4-5):270-283
pubmed: 31340207
J Psychiatr Res. 2011 May;45(5):577-87
pubmed: 20934190
J Mol Neurosci. 2019 Jul;68(3):389-396
pubmed: 30498985
Neuroimage. 2002 Jan;15(1):273-89
pubmed: 11771995
Gut. 1984 Jan;25(1):57-61
pubmed: 6360814
Regul Pept. 2009 Aug 7;156(1-3):42-6
pubmed: 19465061
Peptides. 2009 Aug;30(8):1497-501
pubmed: 19467283
Neuropsychologia. 2020 Aug;145:106564
pubmed: 29157997
J Psychosom Res. 2002 Feb;52(2):69-77
pubmed: 11832252
Neurobiol Learn Mem. 2014 Jul;112:2-16
pubmed: 24583373
Front Psychiatry. 2014 Feb 19;5:17
pubmed: 24600410
Peptides. 1990 Sep-Oct;11(5):933-8
pubmed: 2178250
Brain Res. 1979 Sep 7;173(1):174-8
pubmed: 158404
Peptides. 1988 Jul-Aug;9(4):787-93
pubmed: 3226955
Mol Neurobiol. 1989 Winter;3(4):201-36
pubmed: 2698176
Biol Psychiatry. 2008 Nov 15;64(10):907-11
pubmed: 18657799
Brain Connect. 2012;2(3):125-41
pubmed: 22642651
Nat Rev Immunol. 2016 Jan;16(1):22-34
pubmed: 26711676
Arch Gen Psychiatry. 2009 Dec;66(12):1361-72
pubmed: 19996041
BMC Neurosci. 2008 Jul 10;9:63
pubmed: 18616823
Acta Neurobiol Exp (Wars). 2014;74(3):317-27
pubmed: 25231851
PLoS One. 2012;7(11):e50050
pubmed: 23209643
Pharmacol Rep. 2005 May-Jun;57(3):307-20
pubmed: 15985713
Neurosci Biobehav Rev. 2018 May;88:16-25
pubmed: 29530516
Proteomics. 2018 Apr;18(7):e1700408
pubmed: 29406625
Peptides. 2003 Mar;24(3):437-44
pubmed: 12732342
Science. 1976 May 28;192(4242):907-8
pubmed: 1273576
J Neurosci. 2005 Sep 7;25(36):8303-10
pubmed: 16148238
Neuroimage. 2007 Oct 15;38(1):95-113
pubmed: 17761438
J Neurosci. 2000 Nov 1;20(21):8012-20
pubmed: 11050122
Cell Tissue Res. 2019 Jan;375(1):287-293
pubmed: 30535799
Neuroimage. 2011 Jun 1;56(3):881-9
pubmed: 21356318
Behav Brain Res. 2011 Oct 1;223(2):403-10
pubmed: 21536077
Neuropsychopharmacology. 2010 Jan;35(1):169-91
pubmed: 19625997
Front Neuroendocrinol. 2020 Jan;56:100800
pubmed: 31654681
Neuroscience. 2011 Aug 25;189:359-69
pubmed: 21664438
Brain Struct Funct. 2017 Dec;222(9):3915-3925
pubmed: 28512686
J Neurosci. 2009 Sep 16;29(37):11614-8
pubmed: 19759308
J Neurosci. 2018 Aug 1;38(31):6983-7003
pubmed: 29954847
Cereb Cortex. 2011 Jul;21(7):1667-73
pubmed: 21127016

Auteurs

Rozalyn A Simon (RA)

Center for Medical Image Science and Visualization (CMIV), Linköping University, Linköping, Sweden.
Division of Diagnostics and Specialist Medicine, Department of Health, Medicine, and Caring Sciences, Linköping University, Linköping, Sweden.

Nawroz Barazanji (N)

Division of Inflammation and Infection, Department of Biomedical and Clinical Sciences, Linköping University, Linköping, Sweden.

Michael P Jones (MP)

Department of Psychology, Macquarie University, Sydney, Australia.

Olga Bednarska (O)

Division of Inflammation and Infection, Department of Biomedical and Clinical Sciences, Linköping University, Linköping, Sweden.

Adriane Icenhour (A)

Center for Medical Image Science and Visualization (CMIV), Linköping University, Linköping, Sweden.
Institute of Medical Psychology and Behavioral Immunobiology, University Hospital Essen, University of Duisburg-Essen, Essen, Germany.

Maria Engström (M)

Center for Medical Image Science and Visualization (CMIV), Linköping University, Linköping, Sweden.
Division of Diagnostics and Specialist Medicine, Department of Health, Medicine, and Caring Sciences, Linköping University, Linköping, Sweden.

J Paul Hamilton (JP)

Department of Biomedical and Clinical Sciences, Center for Social and Affective Neuroscience, Linköping University, Linköping, Sweden.

Åsa V Keita (ÅV)

Division of Surgery, Orthopedics and Oncology, Department of Biomedical and Clinical Sciences, Linköping University, Linköping, Sweden.

Susanna Walter (S)

Center for Medical Image Science and Visualization (CMIV), Linköping University, Linköping, Sweden. susanna.walter@liu.se.
Division of Inflammation and Infection, Department of Biomedical and Clinical Sciences, Linköping University, Linköping, Sweden. susanna.walter@liu.se.

Articles similaires

[Redispensing of expensive oral anticancer medicines: a practical application].

Lisanne N van Merendonk, Kübra Akgöl, Bastiaan Nuijen
1.00
Humans Antineoplastic Agents Administration, Oral Drug Costs Counterfeit Drugs

Smoking Cessation and Incident Cardiovascular Disease.

Jun Hwan Cho, Seung Yong Shin, Hoseob Kim et al.
1.00
Humans Male Smoking Cessation Cardiovascular Diseases Female

Evaluation of Low-Value Services Across Major Medicare Advantage Insurers and Traditional Medicare.

Ciara Duggan, Adam L Beckman, Ishani Ganguli et al.
1.00
Humans United States Aged Cross-Sectional Studies Medicare Part C

Effectiveness of Virtual Yoga for Chronic Low Back Pain: A Randomized Clinical Trial.

Hallie Tankha, Devyn Gaskins, Amanda Shallcross et al.
1.00
Humans Yoga Low Back Pain Female Male

Classifications MeSH

questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Vasoactive intestinal polypeptide plasma...
questionsmedicales.fr › Comportement et mécanismes comportementaux › Émotions › Anxiété › Vasoactive intestinal polypeptide plasma...
questionsmedicales.fr › Système nerveux › Système nerveux central › Encéphale › Vasoactive intestinal polypeptide plasma...
questionsmedicales.fr › Comportement et mécanismes comportementaux › Émotions › Dépression › Vasoactive intestinal polypeptide plasma...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Vasoactive intestinal polypeptide plasma...
questionsmedicales.fr › Diagnostic › Techniques et procédures diagnostiques › Imagerie diagnostique › Tomographie › Imagerie par résonance magnétique › Vasoactive intestinal polypeptide plasma...
questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Adulte d'âge moyen › Vasoactive intestinal polypeptide plasma...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines de tissu nerveux › Neuropeptides › Peptide vasoactif intestinal › Vasoactive intestinal polypeptide plasma...