The role of Toll-like receptor 9 in a murine model of Cryptococcus gattii infection.
Journal
Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288
Informations de publication
Date de publication:
14 01 2021
14 01 2021
Historique:
received:
15
09
2020
accepted:
31
12
2020
entrez:
15
1
2021
pubmed:
16
1
2021
medline:
12
8
2021
Statut:
epublish
Résumé
Toll-like receptor 9 (TLR9) is crucial to the host immune response against fungi, such as Candida albicans, Aspergillus fumigatus and Cryptococcus neoformans, but its importance in Cryptococcus gattii infection is unknown. Our study aimed to understand the role of TLR9 during the course of experimental C. gattii infection in vivo, considering that the cryptococcal DNA interaction with the receptor could contribute to host immunity even in an extremely susceptible model. We inoculated C57BL/6 (WT) and TLR9 knock-out (TLR9
Identifiants
pubmed: 33446850
doi: 10.1038/s41598-021-80959-5
pii: 10.1038/s41598-021-80959-5
pmc: PMC7809259
doi:
Substances chimiques
Tlr9 protein, mouse
0
Toll-Like Receptor 9
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
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