An Autochthonous Mouse Model of Myd88- and BCL2-Driven Diffuse Large B-cell Lymphoma Reveals Actionable Molecular Vulnerabilities.

Animals Genes, bcl-2 Germinal Center / metabolism Lymphoma, Large B-Cell, Diffuse / genetics Mice Myeloid Differentiation Factor 88 / genetics Proto-Oncogene Proteins c-bcl-2 / genetics

Journal

Blood cancer discovery
ISSN: 2643-3249
Titre abrégé: Blood Cancer Discov
Pays: United States
ID NLM: 101764786

Informations de publication

Date de publication:
01 2021
Historique:
entrez: 15 1 2021
pubmed: 16 1 2021
medline: 16 1 2021
Statut: ppublish

Résumé

Based on gene expression profiles, diffuse large B cell lymphoma (DLBCL) is sub-divided into germinal center B cell-like (GCB) and activated B cell-like (ABC) DLBCL. Two of the most common genomic aberrations in ABC-DLBCL are mutations in

Identifiants

DOI: 10.1158/2643-3230.BCD-19-0059 PMID: 33447829 PMC: PMC7806186
pubmed: 33447829
doi: 10.1158/2643-3230.BCD-19-0059
pmc: PMC7806186
mid: NIHMS1651272
pii: 2643-3230.BCD-19-0059
doi:

Substances chimiques

Myd88 protein, mouse 0
Myeloid Differentiation Factor 88 0
Proto-Oncogene Proteins c-bcl-2 0

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Langues

eng

Pagination

70-91

Subventions

Organisme : NCI NIH HHS
ID : R01 CA172492
Pays : United States

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Auteurs

Ruth Flümann (R)

University of Cologne, Faculty of Medicine and University Hospital Cologne, Clinic I of Internal Medicine, Cologne, Germany.
Center for Integrated Oncology, University of Cologne, Cologne, Germany.
Center for Molecular Medicine, University of Cologne, Cologne, Germany.
Cologne Excellence Cluster on Cellular Stress Response in Aging-Associated Diseases (CECAD), University of Cologne, Cologne, Germany.

Tim Rehkämper (T)

University of Cologne, Faculty of Medicine and University Hospital Cologne, Clinic I of Internal Medicine, Cologne, Germany.
Center for Integrated Oncology, University of Cologne, Cologne, Germany.
Center for Molecular Medicine, University of Cologne, Cologne, Germany.
Cologne Excellence Cluster on Cellular Stress Response in Aging-Associated Diseases (CECAD), University of Cologne, Cologne, Germany.

Pascal Nieper (P)

University of Cologne, Faculty of Medicine and University Hospital Cologne, Clinic I of Internal Medicine, Cologne, Germany.
Center for Integrated Oncology, University of Cologne, Cologne, Germany.
Center for Molecular Medicine, University of Cologne, Cologne, Germany.
Cologne Excellence Cluster on Cellular Stress Response in Aging-Associated Diseases (CECAD), University of Cologne, Cologne, Germany.

Pauline Pfeiffer (P)

University of Cologne, Faculty of Medicine and University Hospital Cologne, Clinic I of Internal Medicine, Cologne, Germany.
Center for Integrated Oncology, University of Cologne, Cologne, Germany.
Center for Molecular Medicine, University of Cologne, Cologne, Germany.
Cologne Excellence Cluster on Cellular Stress Response in Aging-Associated Diseases (CECAD), University of Cologne, Cologne, Germany.

Alessandra Holzem (A)

University of Cologne, Faculty of Medicine and University Hospital Cologne, Clinic I of Internal Medicine, Cologne, Germany.
Center for Integrated Oncology, University of Cologne, Cologne, Germany.
Center for Molecular Medicine, University of Cologne, Cologne, Germany.
Cologne Excellence Cluster on Cellular Stress Response in Aging-Associated Diseases (CECAD), University of Cologne, Cologne, Germany.

Sebastian Klein (S)

Faculty of Medicine and University Hospital Cologne, Institute of Pathology, University of Cologne, Cologne, Germany.

Sanil Bhatia (S)

Medical Faculty, Department of Pediatric Oncology, Hematology and Clinical Immunology, Heinrich Heine University Düsseldorf, Düsseldorf, Germany.

Moritz Kochanek (M)

University of Cologne, Faculty of Medicine and University Hospital Cologne, Clinic I of Internal Medicine, Cologne, Germany.
Center for Integrated Oncology, University of Cologne, Cologne, Germany.
Center for Molecular Medicine, University of Cologne, Cologne, Germany.
Cologne Excellence Cluster on Cellular Stress Response in Aging-Associated Diseases (CECAD), University of Cologne, Cologne, Germany.

Ilmars Kisis (I)

University of Cologne, Faculty of Medicine and University Hospital Cologne, Clinic I of Internal Medicine, Cologne, Germany.
Center for Integrated Oncology, University of Cologne, Cologne, Germany.
Center for Molecular Medicine, University of Cologne, Cologne, Germany.
Cologne Excellence Cluster on Cellular Stress Response in Aging-Associated Diseases (CECAD), University of Cologne, Cologne, Germany.

Benedikt W Pelzer (BW)

University of Cologne, Faculty of Medicine and University Hospital Cologne, Clinic I of Internal Medicine, Cologne, Germany.
Center for Integrated Oncology, University of Cologne, Cologne, Germany.
Center for Molecular Medicine, University of Cologne, Cologne, Germany.
Cologne Excellence Cluster on Cellular Stress Response in Aging-Associated Diseases (CECAD), University of Cologne, Cologne, Germany.

Heinz Ahlert (H)

Medical Faculty, Department of Pediatric Oncology, Hematology and Clinical Immunology, Heinrich Heine University Düsseldorf, Düsseldorf, Germany.

Julia Hauer (J)

Department of Pediatrics, Pediatric Hematology and Oncology, University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany.
National Center for Tumor Diseases (NCT), Dresden, Germany.

Alexandra da Palma Guerreiro (A)

University of Cologne, Faculty of Medicine and University Hospital Cologne, Clinic I of Internal Medicine, Cologne, Germany.
Center for Integrated Oncology, University of Cologne, Cologne, Germany.
Cologne Excellence Cluster on Cellular Stress Response in Aging-Associated Diseases (CECAD), University of Cologne, Cologne, Germany.

Jeremy A Ryan (JA)

Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts.
ORCID: 0000-0002-3327-1283

Maurice Reimann (M)

Charité Universitätsmedizin Berlin, Medical Department of Hematology, Oncology and Tumor Immunology, and Molekulares Krebsforschungszentrum - MKFZ, Virchow Campus, Berlin, Germany.

Arina Riabinska (A)

University of Cologne, Faculty of Medicine and University Hospital Cologne, Clinic I of Internal Medicine, Cologne, Germany.
Center for Integrated Oncology, University of Cologne, Cologne, Germany.
Center for Molecular Medicine, University of Cologne, Cologne, Germany.
Cologne Excellence Cluster on Cellular Stress Response in Aging-Associated Diseases (CECAD), University of Cologne, Cologne, Germany.

Janica Wiederstein (J)

Cologne Excellence Cluster on Cellular Stress Response in Aging-Associated Diseases (CECAD), University of Cologne, Cologne, Germany.

Marcus Krüger (M)

Cologne Excellence Cluster on Cellular Stress Response in Aging-Associated Diseases (CECAD), University of Cologne, Cologne, Germany.

Martina Deckert (M)

Center for Integrated Oncology, University of Cologne, Cologne, Germany.
Faculty of Medicine and University Hospital Cologne, Institute of Neuropathology, University of Cologne, Cologne, Germany.

Janine Altmüller (J)

Cologne Center for Genomics (CCG), University of Cologne, Cologne, Germany.

Andreas R Klatt (AR)

Faculty of Medicine and University Hospital Cologne, Institute of Clinical Chemistry, University of Cologne, Cologne, Germany.

Lukas P Frenzel (LP)

University of Cologne, Faculty of Medicine and University Hospital Cologne, Clinic I of Internal Medicine, Cologne, Germany.
Center for Integrated Oncology, University of Cologne, Cologne, Germany.
Cologne Excellence Cluster on Cellular Stress Response in Aging-Associated Diseases (CECAD), University of Cologne, Cologne, Germany.

Laura Pasqualucci (L)

Department of Pathology and Cell Biology, Institute for Cancer Genetics and the Herbert Irving Comprehensive Cancer Center, Columbia University, New York, New York.
ORCID: 0000-0001-6819-7370

Wendy Béguelin (W)

Division of Hematology/Oncology, Department of Medicine, Weill Cornell Medicine, Cornell University, New York, New York.
ORCID: 0000-0002-4894-9229

Ari M Melnick (AM)

Division of Hematology/Oncology, Department of Medicine, Weill Cornell Medicine, Cornell University, New York, New York.
ORCID: 0000-0002-8074-2287

Sandrine Sander (S)

Adaptive Immunity and Lymphoma Group, German Cancer Research Center/National Center for Tumor Diseases Heidelberg, Heidelberg, Germany.

Manuel Montesinos-Rongen (M)

Center for Integrated Oncology, University of Cologne, Cologne, Germany.
Faculty of Medicine and University Hospital Cologne, Institute of Neuropathology, University of Cologne, Cologne, Germany.
ORCID: 0000-0003-4724-5526

Anna Brunn (A)

Center for Integrated Oncology, University of Cologne, Cologne, Germany.
Faculty of Medicine and University Hospital Cologne, Institute of Neuropathology, University of Cologne, Cologne, Germany.

Philipp Lohneis (P)

Center for Integrated Oncology, University of Cologne, Cologne, Germany.
Center for Molecular Medicine, University of Cologne, Cologne, Germany.
Faculty of Medicine and University Hospital Cologne, Institute of Pathology, University of Cologne, Cologne, Germany.

Reinhard Büttner (R)

Center for Integrated Oncology, University of Cologne, Cologne, Germany.
Center for Molecular Medicine, University of Cologne, Cologne, Germany.
Faculty of Medicine and University Hospital Cologne, Institute of Pathology, University of Cologne, Cologne, Germany.

Hamid Kashkar (H)

Center for Molecular Medicine, University of Cologne, Cologne, Germany.
Cologne Excellence Cluster on Cellular Stress Response in Aging-Associated Diseases (CECAD), University of Cologne, Cologne, Germany.
Faculty of Medicine and University Hospital Cologne, Institute for Medical Microbiology, Immunology and Hygiene, University of Cologne, Cologne, Germany.
ORCID: 0000-0003-2796-1429

Arndt Borkhardt (A)

Medical Faculty, Department of Pediatric Oncology, Hematology and Clinical Immunology, Heinrich Heine University Düsseldorf, Düsseldorf, Germany.

Anthony Letai (A)

Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts.

Thorsten Persigehl (T)

Center for Integrated Oncology, University of Cologne, Cologne, Germany.
Faculty of Medicine and University Hospital Cologne, Department of Radiology and Interventional Radiology, University of Cologne, Cologne, Germany.

Martin Peifer (M)

Center for Integrated Oncology, University of Cologne, Cologne, Germany.
Center for Molecular Medicine, University of Cologne, Cologne, Germany.
Department of Translational Genomics, University of Cologne, Cologne, Germany.

Clemens A Schmitt (CA)

Charité Universitätsmedizin Berlin, Medical Department of Hematology, Oncology and Tumor Immunology, and Molekulares Krebsforschungszentrum - MKFZ, Virchow Campus, Berlin, Germany.
Kepler Universitätsklinikum, Medical Department of Hematology and Oncology, Johannes Kepler University, Linz, Austria.
ORCID: 0000-0002-4731-2226

Hans Christian Reinhardt (HC)

Department of Hematology and Stem Cell Transplantation, University Hospital Essen, University Duisburg-Essen, German Cancer Consortium (DKTK Partner Site Essen), Essen, Germany. christian.reinhardt@uk-essen.de.
ORCID: 0000-0001-5706-9349

Gero Knittel (G)

University of Cologne, Faculty of Medicine and University Hospital Cologne, Clinic I of Internal Medicine, Cologne, Germany.
Center for Integrated Oncology, University of Cologne, Cologne, Germany.
Center for Molecular Medicine, University of Cologne, Cologne, Germany.
Cologne Excellence Cluster on Cellular Stress Response in Aging-Associated Diseases (CECAD), University of Cologne, Cologne, Germany.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › An Autochthonous Mouse Model of Myd88- and...
questionsmedicales.fr › Phénomènes génétiques › Structures génétiques › Génome › Composants de génome › Gènes › Gènes tumoraux › Oncogènes › Proto-oncogènes › Gènes bcl-2 › An Autochthonous Mouse Model of Myd88- and...
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Système lymphatique › Tissu lymphoïde › Noeuds lymphatiques › Centre germinatif › An Autochthonous Mouse Model of Myd88- and...
questionsmedicales.fr › Maladies du système immunitaire › Syndromes immunoprolifératifs › Syndromes lymphoprolifératifs › Lymphomes › Lymphome malin non hodgkinien › Lymphome B › Lymphome B diffus à grandes cellules › An Autochthonous Mouse Model of Myd88- and...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › An Autochthonous Mouse Model of Myd88- and...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines et peptides de signalisation intracellulaire › Protéines adaptatrices de la transduction du signal › Facteur de différenciation myéloïde-88 › An Autochthonous Mouse Model of Myd88- and...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines tumorales › Protéines oncogènes › Protéines proto-oncogènes › Protéines proto-oncogènes c-bcl-2 › An Autochthonous Mouse Model of Myd88- and...