A flagellate-to-amoeboid switch in the closest living relatives of animals.
Salpingoeca rosetta
animal origins
cell biology
cell type evolution
cellular proprioception
choanoflagellates
evolutionary biology
transdifferentiation
Journal
eLife
ISSN: 2050-084X
Titre abrégé: Elife
Pays: England
ID NLM: 101579614
Informations de publication
Date de publication:
15 01 2021
15 01 2021
Historique:
received:
14
07
2020
accepted:
14
01
2021
pubmed:
16
1
2021
medline:
4
2
2022
entrez:
15
1
2021
Statut:
epublish
Résumé
Amoeboid cell types are fundamental to animal biology and broadly distributed across animal diversity, but their evolutionary origin is unclear. The closest living relatives of animals, the choanoflagellates, display a polarized cell architecture (with an apical flagellum encircled by microvilli) that resembles that of epithelial cells and suggests homology, but this architecture differs strikingly from the deformable phenotype of animal amoeboid cells, which instead evoke more distantly related eukaryotes, such as diverse amoebae. Here, we show that choanoflagellates subjected to confinement become amoeboid by retracting their flagella and activating myosin-based motility. This switch allows escape from confinement and is conserved across choanoflagellate diversity. The conservation of the amoeboid cell phenotype across animals and choanoflagellates, together with the conserved role of myosin, is consistent with homology of amoeboid motility in both lineages. We hypothesize that the differentiation between animal epithelial and crawling cells might have evolved from a stress-induced switch between flagellate and amoeboid forms in their single-celled ancestors.
Identifiants
pubmed: 33448265
doi: 10.7554/eLife.61037
pii: 61037
pmc: PMC7895527
doi:
pii:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Howard Hughes Medical Institute
Pays : United States
Commentaires et corrections
Type : CommentIn
Informations de copyright
© 2021, Brunet et al.
Déclaration de conflit d'intérêts
TB, MA, WR, MC, DS, NK No competing interests declared
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