Digestive n-6 Lipid Oxidation, a Key Trigger of Vascular Dysfunction and Atherosclerosis in the Western Diet: Protective Effects of Apple Polyphenols.
Aldehydes
/ analysis
Animals
Atherosclerosis
/ etiology
Diet, Western
/ adverse effects
Dietary Supplements
Fatty Acids, Omega-6
/ metabolism
Lipoproteins, LDL
/ blood
Male
Malus
/ chemistry
Mice, Inbred C57BL
Mice, Knockout, ApoE
Nitric Oxide
/ metabolism
Oxidation-Reduction
Plaque, Atherosclerotic
/ diagnostic imaging
Polyphenols
/ chemistry
Reactive Oxygen Species
/ metabolism
4-hydroxy-2-nonenal
Western diet
atherosclerosis
endothelial function
polyphenols
Journal
Molecular nutrition & food research
ISSN: 1613-4133
Titre abrégé: Mol Nutr Food Res
Pays: Germany
ID NLM: 101231818
Informations de publication
Date de publication:
03 2021
03 2021
Historique:
revised:
04
01
2021
received:
14
06
2020
pubmed:
16
1
2021
medline:
10
11
2021
entrez:
15
1
2021
Statut:
ppublish
Résumé
A main risk factor of atherosclerosis is a Western diet (WD) rich in n-6 polyunsaturated fatty acids (PUFAs) sensitive to oxidation. Their oxidation can be initiated by heme iron of red meat leading to the formation of 4-hydroxy-2-nonenal (4-HNE), a cytotoxic aldehyde. An increased 4-HNE production is implicated in endothelial dysfunction and atherosclerosis. By contrast, a diet rich in proanthocyanidins reduces oxidative stress and arterial diseases. This study evaluates the effects of a WD on vascular integrity in ApolipoproteinE (ApoE ApoE n-6 lipid oxidation during digestion may be a key factor of vascular impairments. Nevertheless, an antioxidant strategy can limit 4-HNE formation during digestion and thus durably protect vascular function.
Identifiants
pubmed: 33450108
doi: 10.1002/mnfr.202000487
doi:
Substances chimiques
Aldehydes
0
Fatty Acids, Omega-6
0
Lipoproteins, LDL
0
Polyphenols
0
Reactive Oxygen Species
0
oxidized low density lipoprotein
0
Nitric Oxide
31C4KY9ESH
4-hydroxy-2-nonenal
K1CVM13F96
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
e2000487Informations de copyright
© 2021 Wiley-VCH GmbH.
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