PD-1 blockade exacerbates


Journal

Science immunology
ISSN: 2470-9468
Titre abrégé: Sci Immunol
Pays: United States
ID NLM: 101688624

Informations de publication

Date de publication:
15 01 2021
Historique:
received: 22 10 2020
accepted: 10 12 2020
entrez: 16 1 2021
pubmed: 17 1 2021
medline: 22 2 2022
Statut: ppublish

Résumé

Boosting immune cell function by targeting the coinhibitory receptor PD-1 may have applications in the treatment of chronic infections. Here, we examine the role of PD-1 during

Identifiants

pubmed: 33452107
pii: 6/55/eabf3861
doi: 10.1126/sciimmunol.abf3861
pmc: PMC8300572
mid: NIHMS1712916
pii:
doi:

Substances chimiques

CTLA-4 Antigen 0
Immune Checkpoint Inhibitors 0
Programmed Cell Death 1 Receptor 0

Types de publication

Journal Article Research Support, N.I.H., Extramural

Langues

eng

Sous-ensembles de citation

IM

Subventions

Organisme : NIAID NIH HHS
ID : P01 AI056299
Pays : United States
Organisme : NIAID NIH HHS
ID : R37 AI112787
Pays : United States
Organisme : Intramural NIH HHS
ID : ZIA AI001171
Pays : United States

Informations de copyright

Copyright © 2021 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works.

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Auteurs

Keith D Kauffman (KD)

T Lymphocyte Biology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.

Shunsuke Sakai (S)

T Lymphocyte Biology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.

Nickiana E Lora (NE)

T Lymphocyte Biology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.

Sivaranjani Namasivayam (S)

Immunobiology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.

Paul J Baker (PJ)

Inflammation and Innate Immunity Unit, Laboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.

Olena Kamenyeva (O)

Biological Imaging Section, Research Technologies Branch, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.

Taylor W Foreman (TW)

T Lymphocyte Biology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.

Christine E Nelson (CE)

T Lymphocyte Biology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.

Deivide Oliveira-de-Souza (D)

Multinational Organization Network Sponsoring Translational and Epidemiological Research (MONSTER) Initiative, Intituto Gonçalo Moniz, Fundação Oswaldo Cruz, Salvador, Brazil.

Caian L Vinhaes (CL)

Multinational Organization Network Sponsoring Translational and Epidemiological Research (MONSTER) Initiative, Intituto Gonçalo Moniz, Fundação Oswaldo Cruz, Salvador, Brazil.

Ziv Yaniv (Z)

Office of Cyber Infrastructure and Computational Biology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.

Cecilia S Lindestam Arleham (CS)

Division of Vaccine Discovery, La Jolla Institute for Immunology, La Jolla, CA, USA.

Alessandro Sette (A)

Division of Vaccine Discovery, La Jolla Institute for Immunology, La Jolla, CA, USA.
Department of Medicine, University of California, San Diego, La Jolla, CA, USA.

Gordon J Freeman (GJ)

Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA.

Rashida Moore (R)

Comparative Medicine Branch, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.

Alan Sher (A)

Immunobiology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.

Katrin D Mayer-Barber (KD)

Inflammation and Innate Immunity Unit, Laboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.

Bruno B Andrade (BB)

Multinational Organization Network Sponsoring Translational and Epidemiological Research (MONSTER) Initiative, Intituto Gonçalo Moniz, Fundação Oswaldo Cruz, Salvador, Brazil.

Juraj Kabat (J)

Biological Imaging Section, Research Technologies Branch, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.

Laura E Via (LE)

Tuberculosis Research Section, Laboratory of Clinical Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.

Daniel L Barber (DL)

T Lymphocyte Biology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA. barberd@niaid.nih.gov.

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Classifications MeSH