NTPDase8 protects mice from intestinal inflammation by limiting P2Y
Adenosine Triphosphatases
/ genetics
Animals
Apoptosis
Bone Marrow Transplantation
Colitis
/ metabolism
Colon
/ metabolism
Cytokines
/ metabolism
Dextran Sulfate
/ pharmacology
Disease Models, Animal
Epithelial Cells
/ metabolism
Humans
Immunohistochemistry
Intestinal Mucosa
/ metabolism
Isothiocyanates
/ pharmacology
Mice, Inbred C57BL
Mice, Knockout
RNA, Messenger
/ metabolism
Real-Time Polymerase Chain Reaction
Receptors, Purinergic P2
/ genetics
Reverse Transcriptase Polymerase Chain Reaction
Thiourea
/ analogs & derivatives
gastrointestinal immune response
inflammatory bowel disease
intestinal epithelium
Journal
Gut
ISSN: 1468-3288
Titre abrégé: Gut
Pays: England
ID NLM: 2985108R
Informations de publication
Date de publication:
01 2022
01 2022
Historique:
received:
19
02
2020
revised:
29
12
2020
accepted:
04
01
2021
pubmed:
17
1
2021
medline:
11
1
2022
entrez:
16
1
2021
Statut:
ppublish
Résumé
Nucleotides are danger signals that activate inflammatory responses via binding P2 receptors. The nucleoside triphosphate diphosphohydrolase-8 (NTPDase8) is an ectonucleotidase that hydrolyses P2 receptor ligands. We investigated the role of NTPDase8 in intestinal inflammation. We generated NTPDase8-deficient ( NTPDase8 is the dominant enzyme responsible for the hydrolysis of nucleotides in the lumen of the colon. Compared with wild-type (WT) control mice, the colon of NTPDase8 protects the intestine from inflammation most probably by limiting the activation of P2Y
Identifiants
pubmed: 33452178
pii: gutjnl-2020-320937
doi: 10.1136/gutjnl-2020-320937
doi:
Substances chimiques
Cytokines
0
Isothiocyanates
0
N,N''-1,4-butanediylbis(N'-(3-isothiocyanatophenyl))thiourea
0
RNA, Messenger
0
Receptors, Purinergic P2
0
purinoceptor P2Y6
0
Dextran Sulfate
9042-14-2
Adenosine Triphosphatases
EC 3.6.1.-
nucleoside triphosphate diphosphohydrolase 8, mouse
EC 3.6.1.3
Thiourea
GYV9AM2QAG
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
43-54Informations de copyright
© Author(s) (or their employer(s)) 2022. No commercial re-use. See rights and permissions. Published by BMJ.
Déclaration de conflit d'intérêts
Competing interests: None declared.