CD79a promotes CNS-infiltration and leukemia engraftment in pediatric B-cell precursor acute lymphoblastic leukemia.
Journal
Communications biology
ISSN: 2399-3642
Titre abrégé: Commun Biol
Pays: England
ID NLM: 101719179
Informations de publication
Date de publication:
15 01 2021
15 01 2021
Historique:
received:
30
06
2020
accepted:
25
11
2020
entrez:
16
1
2021
pubmed:
17
1
2021
medline:
29
6
2021
Statut:
epublish
Résumé
Central nervous system (CNS) involvement remains a challenge in the diagnosis and treatment of acute lymphoblastic leukemia (ALL). In this study, we identify CD79a (also known as Igα), a signaling component of the preB cell receptor (preBCR), to be associated with CNS-infiltration and -relapse in B-cell precursor (BCP)-ALL patients. Furthermore, we show that downregulation of CD79a hampers the engraftment of leukemia cells in different murine xenograft models, particularly in the CNS.
Identifiants
pubmed: 33452446
doi: 10.1038/s42003-020-01591-z
pii: 10.1038/s42003-020-01591-z
pmc: PMC7810877
doi:
Substances chimiques
CD79 Antigens
0
CD79A protein, human
0
src-Family Kinases
EC 2.7.10.2
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
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