Meta-analysis of sample-level dbGaP data reveals novel shared genetic link between body height and Crohn's disease.
Adult
Body Height
/ genetics
Child
Crohn Disease
/ genetics
Databases, Genetic
Diabetes Mellitus, Type 2
/ genetics
Female
Gene Expression Regulation
Genetic Predisposition to Disease
Humans
Immune Checkpoint Proteins
/ genetics
Immunity, Innate
Intercellular Signaling Peptides and Proteins
/ genetics
Male
Multifactorial Inheritance
/ immunology
Myocardial Infarction
/ genetics
Phenotype
Risk Factors
Journal
Human genetics
ISSN: 1432-1203
Titre abrégé: Hum Genet
Pays: Germany
ID NLM: 7613873
Informations de publication
Date de publication:
Jun 2021
Jun 2021
Historique:
received:
02
09
2020
accepted:
19
12
2020
pubmed:
17
1
2021
medline:
13
5
2021
entrez:
16
1
2021
Statut:
ppublish
Résumé
To further explore genetic links between complex traits, we developed a comprehensive framework to harmonize and integrate extensive genotype and phenotype data from the four well-characterized cohorts with the focus on cardiometabolic diseases deposited to the database of Genotypes and Phenotypes (dbGaP). We generated a series of polygenic risk scores (PRS) to investigate pleiotropic effects of loci that confer genetic risk for 19 common diseases and traits on body height, type 2 diabetes (T2D), and myocardial infarction (MI). In a meta-analysis of 20,021 subjects, we identified shared genetic determinants of Crohn's Disease (CD), a type of inflammatory bowel disease, and body height (p = 5.5 × 10
Identifiants
pubmed: 33452914
doi: 10.1007/s00439-020-02250-3
pii: 10.1007/s00439-020-02250-3
pmc: PMC8102349
mid: NIHMS1668094
doi:
Substances chimiques
Immune Checkpoint Proteins
0
Intercellular Signaling Peptides and Proteins
0
Types de publication
Journal Article
Meta-Analysis
Langues
eng
Sous-ensembles de citation
IM
Pagination
865-877Subventions
Organisme : NIDDK NIH HHS
ID : U24DK062429
Pays : United States
Organisme : NIDA NIH HHS
ID : DA047045
Pays : United States
Organisme : NHLBI NIH HHS
ID : HL125027
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01DK106593
Pays : United States
Organisme : NHGRI NIH HHS
ID : R01 HG010649
Pays : United States
Organisme : Medical Research Council
ID : MC_PC_17228
Pays : United Kingdom
Organisme : Medical Research Council
ID : MC_QA137853
Pays : United Kingdom
Organisme : NIDDK NIH HHS
ID : U24 DK062429
Pays : United States
Organisme : NIEHS NIH HHS
ID : R01 ES029212
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01 DK106593
Pays : United States
Organisme : NHGRI NIH HHS
ID : HG010649
Pays : United States
Organisme : NIDA NIH HHS
ID : R01 DA047045
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL125027
Pays : United States
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