Evaluation of sympathetic adrenergic branch of cutaneous neural control throughout thermography and its relationship to nitric oxide levels in patients with fibromyalgia.
Core body temperature
Fibromyalgia
Microcirculation
Nitric oxide
Peripheral nervous system
Thermography
Journal
Journal of thermal biology
ISSN: 0306-4565
Titre abrégé: J Therm Biol
Pays: England
ID NLM: 7600115
Informations de publication
Date de publication:
Jan 2021
Jan 2021
Historique:
received:
24
06
2020
revised:
11
11
2020
accepted:
12
12
2020
entrez:
17
1
2021
pubmed:
18
1
2021
medline:
29
9
2021
Statut:
ppublish
Résumé
Fibromyalgia syndrome is defined as a complex disease, characterized by chronic widespread musculoskeletal pain and other symptoms. The factors underlying physiopathology of fibromyalgia are not well understood, complicating its diagnosis and management. To evaluate the peripheral vascular blood flow of the skin of the hands and the core body temperature as indirect measures of sympathetic adrenergic activity of the nervous system and its relationship to nitric oxide levels (NO) in women with fibromyalgia compared with healthy controls. Forty-two women with fibromyalgia and 52 healthy women were enrolled in this observational pilot study. We used infrared thermography of the hands and an infrared dermal thermometer to evaluate the peripheral vascular blood flow and tympanic and axillary core body temperature, respectively. We measured NO levels using the ozone chemiluminescence-based method. Two-way analysis of covariance (ANCOVA) showed that the tympanic (P=0.002) and hand temperatures were significantly higher in the patients with fibromyalgia than in the controls (P≤0.001). Significant associations were also found between serum NO levels and minimum temperatures at the dorsal center of the dominant hand (β=-3.501; 95% confidence interval [CI] -6.805, ‑0.198; P= 0.038), maximum temperature (β=-5.594; 95% CI ‑10.106, ‑1.081; P=0.016), minimum temperature (β=-4.090; 95% CI ‑7.905, ‑0.275; P=0.036), and mean temperature (β=-5.519; 95% CI ‑9.933, ‑1.106; P=0.015) of the center of the palm of the non-dominant hand, maximum temperature at the thenar eminence of the dominant hand (β=-5.800; 95% CI ‑10.508, ‑1.092; P=0.017), and tympanic temperature (β=-9.321; 95% CI ‑17.974, ‑0.669; P=0.035) in the controls. Our findings indicate that the women with fibromyalgia showed higher tympanic core body and hand temperature than the healthy controls. Moreover, there were negative associations between hand peripheral vasodilation and NO in the healthy women but not in those with fibromyalgia, suggesting a dysfunction of sympathetic cutaneous neural control.
Sections du résumé
BACKGROUND
BACKGROUND
Fibromyalgia syndrome is defined as a complex disease, characterized by chronic widespread musculoskeletal pain and other symptoms. The factors underlying physiopathology of fibromyalgia are not well understood, complicating its diagnosis and management.
OBJECTIVES
OBJECTIVE
To evaluate the peripheral vascular blood flow of the skin of the hands and the core body temperature as indirect measures of sympathetic adrenergic activity of the nervous system and its relationship to nitric oxide levels (NO) in women with fibromyalgia compared with healthy controls.
METHODS
METHODS
Forty-two women with fibromyalgia and 52 healthy women were enrolled in this observational pilot study. We used infrared thermography of the hands and an infrared dermal thermometer to evaluate the peripheral vascular blood flow and tympanic and axillary core body temperature, respectively. We measured NO levels using the ozone chemiluminescence-based method.
RESULTS
RESULTS
Two-way analysis of covariance (ANCOVA) showed that the tympanic (P=0.002) and hand temperatures were significantly higher in the patients with fibromyalgia than in the controls (P≤0.001). Significant associations were also found between serum NO levels and minimum temperatures at the dorsal center of the dominant hand (β=-3.501; 95% confidence interval [CI] -6.805, ‑0.198; P= 0.038), maximum temperature (β=-5.594; 95% CI ‑10.106, ‑1.081; P=0.016), minimum temperature (β=-4.090; 95% CI ‑7.905, ‑0.275; P=0.036), and mean temperature (β=-5.519; 95% CI ‑9.933, ‑1.106; P=0.015) of the center of the palm of the non-dominant hand, maximum temperature at the thenar eminence of the dominant hand (β=-5.800; 95% CI ‑10.508, ‑1.092; P=0.017), and tympanic temperature (β=-9.321; 95% CI ‑17.974, ‑0.669; P=0.035) in the controls.
CONCLUSIONS
CONCLUSIONS
Our findings indicate that the women with fibromyalgia showed higher tympanic core body and hand temperature than the healthy controls. Moreover, there were negative associations between hand peripheral vasodilation and NO in the healthy women but not in those with fibromyalgia, suggesting a dysfunction of sympathetic cutaneous neural control.
Identifiants
pubmed: 33454042
pii: S0306-4565(20)30584-2
doi: 10.1016/j.jtherbio.2020.102813
pii:
doi:
Substances chimiques
Nitric Oxide
31C4KY9ESH
Types de publication
Journal Article
Observational Study
Langues
eng
Sous-ensembles de citation
IM
Pagination
102813Informations de copyright
Copyright © 2020 Elsevier Ltd. All rights reserved.