Relationship between dietary factors and S-Klotho plasma levels in young sedentary healthy adults.
Adolescent
Adult
Age Factors
Alcohol Drinking
/ adverse effects
Biomarkers
/ blood
Body Composition
Cardiometabolic Risk Factors
Cross-Sectional Studies
Diet
/ adverse effects
Feeding Behavior
Female
Glucuronidase
/ blood
Healthy Volunteers
Humans
Klotho Proteins
Male
Nutritive Value
Risk Assessment
Sedentary Behavior
Sex Factors
Uric Acid
/ blood
Young Adult
Aging
Alcohol
Diet
Dietary inflammatory index
Lean mass
Uric acid
Journal
Mechanisms of ageing and development
ISSN: 1872-6216
Titre abrégé: Mech Ageing Dev
Pays: Ireland
ID NLM: 0347227
Informations de publication
Date de publication:
03 2021
03 2021
Historique:
received:
19
10
2020
revised:
11
01
2021
accepted:
11
01
2021
pubmed:
18
1
2021
medline:
11
11
2021
entrez:
17
1
2021
Statut:
ppublish
Résumé
To study the associations of dietary factors with S-Klotho plasma levels in young adults. We also aimed to study whether body composition and cardiometabolic risk factors affected the association between dietary factors and S-Klotho plasma levels. A total of 139 young adults took part in this study. Dietary factors were measured using a food frequency questionnaire and three non-consecutive 24 h recalls. S-Klotho plasma levels were measured by immunosorbent assay. Body composition was measured by DXA. We observed a direct association of ethanol intake and S-Klotho plasma levels in women. An inverse association was also observed between the dietary inflammatory index (DII) with S-Klotho plasma levels in all sample. No mediation effects of body composition or cardiometabolic risk factors were observed in the relationship between alcohol and S-Klotho plasma levels. Lean mass index (LMI) and uric acid levels mediated the relationship between DII and S-Klotho plasma levels. A pro-inflammatory dietary pattern was inversely associated with S-Klotho plasma levels in young adults, which was partially mediated by LMI and uric acid levels.
Identifiants
pubmed: 33454278
pii: S0047-6374(21)00007-5
doi: 10.1016/j.mad.2021.111435
pii:
doi:
Substances chimiques
Biomarkers
0
Uric Acid
268B43MJ25
Glucuronidase
EC 3.2.1.31
Klotho Proteins
EC 3.2.1.31
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
111435Informations de copyright
Copyright © 2021 Elsevier B.V. All rights reserved.