Dopamine D
Adult
Body Mass Index
Cocaine-Related Disorders
/ pathology
Globus Pallidus
/ diagnostic imaging
Humans
Ligands
Middle Aged
Obesity
/ pathology
Positron-Emission Tomography
Receptors, Dopamine D2
/ metabolism
Receptors, Dopamine D3
/ metabolism
Substantia Nigra
/ diagnostic imaging
Ventral Tegmental Area
/ diagnostic imaging
Addictive behaviors
Cocaine
Dopamine
Obesity
Reward
Substance-related disorders
Journal
Drug and alcohol dependence
ISSN: 1879-0046
Titre abrégé: Drug Alcohol Depend
Pays: Ireland
ID NLM: 7513587
Informations de publication
Date de publication:
01 03 2021
01 03 2021
Historique:
received:
24
08
2020
revised:
14
12
2020
accepted:
14
12
2020
pubmed:
18
1
2021
medline:
22
6
2021
entrez:
17
1
2021
Statut:
ppublish
Résumé
Positron emission tomography (PET) work with the dopamine D3 receptor (D Non-obese CUD subjects (N = 12) were compared to age-matched obese CUD subjects (N = 14). All subjects underwent [ In between-group analyses, D2/3R availability in non-obese and obese CUD groups was not significantly different overall. BMI was inversely correlated withBP These data suggest that obesity in CUD was not associated with significant differences in D
Sections du résumé
BACKGROUND
Positron emission tomography (PET) work with the dopamine D3 receptor (D
METHODS
Non-obese CUD subjects (N = 12) were compared to age-matched obese CUD subjects (N = 14). All subjects underwent [
RESULTS
In between-group analyses, D2/3R availability in non-obese and obese CUD groups was not significantly different overall. BMI was inversely correlated withBP
CONCLUSION
These data suggest that obesity in CUD was not associated with significant differences in D
Identifiants
pubmed: 33454626
pii: S0376-8716(21)00009-0
doi: 10.1016/j.drugalcdep.2021.108514
pmc: PMC7889720
mid: NIHMS1661252
pii:
doi:
Substances chimiques
Ligands
0
Receptors, Dopamine D2
0
Receptors, Dopamine D3
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
108514Subventions
Organisme : NIDA NIH HHS
ID : P20 DA027844
Pays : United States
Organisme : NCATS NIH HHS
ID : UL1 TR001863
Pays : United States
Organisme : NIDA NIH HHS
ID : R03 DA027456
Pays : United States
Organisme : NIMH NIH HHS
ID : T32 MH019961
Pays : United States
Organisme : NIDA NIH HHS
ID : L30 DA029943
Pays : United States
Organisme : NIDA NIH HHS
ID : K24 DA017899
Pays : United States
Informations de copyright
Copyright © 2021 Elsevier B.V. All rights reserved.
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