A multicentre study of naevus-associated melanoma vs. de novo melanoma, tumour thickness and body site differences.
Journal
The British journal of dermatology
ISSN: 1365-2133
Titre abrégé: Br J Dermatol
Pays: England
ID NLM: 0004041
Informations de publication
Date de publication:
07 2021
07 2021
Historique:
accepted:
14
01
2021
pubmed:
18
1
2021
medline:
27
7
2021
entrez:
17
1
2021
Statut:
ppublish
Résumé
Whether melanoma in histological contiguity with a naevus [naevus-associated melanoma (NAM)] is distinctly different from melanoma arising de novo remains unclear. To determine whether the characteristics of de novo melanoma differ from NAM and are not due to naevus obliteration in thicker tumours. We conducted a multicentre retrospective study of de novo melanoma and NAM in seven referral centres in Europe, Australia and the USA between 2006 and 2015. In a total of 9474 localized melanomas, de novo melanoma was associated with thicker tumours and body site differences compared with NAM. In the subset of T Clinicopathological and body site differences between de novo melanoma and NAM support the divergent pathway model of development. These differences were also found in thin melanomas, suggesting that de novo melanomas are different from NAM and their differences are not due to the obliteration of naevus remnants in thicker tumours.
Sections du résumé
BACKGROUND
Whether melanoma in histological contiguity with a naevus [naevus-associated melanoma (NAM)] is distinctly different from melanoma arising de novo remains unclear.
OBJECTIVES
To determine whether the characteristics of de novo melanoma differ from NAM and are not due to naevus obliteration in thicker tumours.
METHODS
We conducted a multicentre retrospective study of de novo melanoma and NAM in seven referral centres in Europe, Australia and the USA between 2006 and 2015.
RESULTS
In a total of 9474 localized melanomas, de novo melanoma was associated with thicker tumours and body site differences compared with NAM. In the subset of T
CONCLUSIONS
Clinicopathological and body site differences between de novo melanoma and NAM support the divergent pathway model of development. These differences were also found in thin melanomas, suggesting that de novo melanomas are different from NAM and their differences are not due to the obliteration of naevus remnants in thicker tumours.
Types de publication
Journal Article
Multicenter Study
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
101-109Commentaires et corrections
Type : CommentIn
Informations de copyright
© 2021 British Association of Dermatologists.
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