Expression of placenta-specific 1 and its potential for eliciting anti-tumor helper T-cell responses in head and neck squamous cell carcinoma.
CD4 T cells
PLAC1
Placenta-specific 1
epitope
head and neck squamous cell carcinoma
helper T lymphocytes
immunotherapy
peptide vaccine
Journal
Oncoimmunology
ISSN: 2162-402X
Titre abrégé: Oncoimmunology
Pays: United States
ID NLM: 101570526
Informations de publication
Date de publication:
29 12 2020
29 12 2020
Historique:
entrez:
18
1
2021
pubmed:
19
1
2021
medline:
29
7
2021
Statut:
epublish
Résumé
Placenta-specific 1 (PLAC1) is expressed primarily in placental trophoblasts but not in normal tissues and is a targetable candidate for cancer immunotherapy because it is a cancer testis antigen known to be up-regulated in various tumors. Although peptide epitopes capable of stimulating CD8 T cells have been previously described, there have been no reports of PLAC1 CD4 helper T lymphocyte (HTL) epitopes and the expression of this antigen in head and neck squamous cell carcinoma (HNSCC). Here, we show that PLAC1 is highly expressed in 74.5% of oropharyngeal and 51.9% of oral cavity tumors from HNSCC patients and in several HNSCC established cell lines. We also identified an HTL peptide epitope (PLAC1
Identifiants
pubmed: 33457076
doi: 10.1080/2162402X.2020.1856545
pii: 1856545
pmc: PMC7781841
doi:
Substances chimiques
Antigens, Neoplasm
0
Epitopes, T-Lymphocyte
0
PLAC1 protein, human
0
Pregnancy Proteins
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1856545Informations de copyright
© 2020 The Author(s). Published with license by Taylor & Francis Group, LLC.
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