miR-362-3p Targets Orosomucoid 1 to Promote Cell Proliferation, Restrain Cell Apoptosis and Thereby Mitigate Hypoxia/Reoxygenation-Induced Cardiomyocytes Injury.
Apoptosis
Caspase 9
Cell Hypoxia
Cell Proliferation
Cells, Cultured
Databases, Genetic
Gene Expression Regulation
Humans
Interleukin-1beta
/ metabolism
MicroRNAs
/ genetics
Mitogen-Activated Protein Kinase 1
/ metabolism
Mitogen-Activated Protein Kinase 3
/ metabolism
Myocardial Reperfusion Injury
/ genetics
Myocytes, Cardiac
/ metabolism
Orosomucoid
/ genetics
Signal Transduction
Apoptosis
Biomarker
Inflammatory factors
Orosomucoid 1
miR-362-3p
Journal
Cardiovascular toxicology
ISSN: 1559-0259
Titre abrégé: Cardiovasc Toxicol
Pays: United States
ID NLM: 101135818
Informations de publication
Date de publication:
05 2021
05 2021
Historique:
received:
17
09
2020
accepted:
30
12
2020
pubmed:
19
1
2021
medline:
27
1
2022
entrez:
18
1
2021
Statut:
ppublish
Résumé
This study aimed to investigate the mechanism of how miR-362-3p/orosomucoid 1 (ORM1) involved in hypoxia/reoxygenation (H/R)-induced cardiomyocytes injury. Based on data obtained from Gene Expression Omnibus (GEO) database, we revealed that ORM1 was highly expressed and positively correlated with the expression of inflammatory factors (MAPK1, MAPK3, IL1B and CASP9). miR-362-3p was identified as an upstream regulatory miRNA of ORM1 and negatively modulated the mRNA and protein expression levels of ORM1 in H/R-injured cardiomyocytes. Moreover, we found that miR-362-3p was downregulated in cardiomyocytes injured by H/R. The promoting influence of miR-362-3p mimic on the proliferation and the inhibitory effect of miR-362-3p mimic on the apoptosis of H/R-stimulated cardiomyocytes were eliminated by overexpression of ORM1. Furthermore, miR-362-3p affected the expression of MAPK1, MAPK3, IL1B and CASP9 in H/R-injured cardiomyocytes through targeting ORM1. Our outcomes illustrated that miR-362-3p exhibited a protective influence on H/R-induced cardiomyocytes through targeting ORM1.
Identifiants
pubmed: 33459949
doi: 10.1007/s12012-020-09631-0
pii: 10.1007/s12012-020-09631-0
doi:
Substances chimiques
IL1B protein, human
0
Interleukin-1beta
0
MIRN362 microRNA, human
0
MicroRNAs
0
ORM1 protein, human
0
Orosomucoid
0
MAPK1 protein, human
EC 2.7.11.24
MAPK3 protein, human
EC 2.7.11.24
Mitogen-Activated Protein Kinase 1
EC 2.7.11.24
Mitogen-Activated Protein Kinase 3
EC 2.7.11.24
CASP9 protein, human
EC 3.4.22.-
Caspase 9
EC 3.4.22.-
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
387-398Références
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