Bone Disruption and Environmental Pollutants.

Animals Bone and Bones Endocrine Disruptors / toxicity Environmental Pollutants / toxicity Estrogens Humans
Endocrine-disrupting chemicals bisphenol A bone metabolism bone turnover cadmium dioxins organotins parabens perfluoroalkyl phthalates polychlorobiphenyls polycyclic aromatic hydrocarbons polyfluoroalkyl

Journal

Endocrine, metabolic & immune disorders drug targets
ISSN: 2212-3873
Titre abrégé: Endocr Metab Immune Disord Drug Targets
Pays: United Arab Emirates
ID NLM: 101269157

Informations de publication

Date de publication:
15 Aug 2022
Historique:
received: 24 08 2020
revised: 06 11 2020
accepted: 24 11 2020
pubmed: 20 1 2021
medline: 20 8 2022
entrez: 19 1 2021
Statut: ppublish

Résumé

Endocrine Disrupting Chemicals (EDCs) are ubiquitous and may significantly contribute to environmental pollution and contamination in humans and wildlife. Ecological pollutants could interfere with bone homeostasis through different mechanisms, including hormonal imbalance, direct osteoblast toxicity, and enhancement of osteoclasts activity, leading to either osteopenia or osteoporosis. Among these chemicals, bisphenols, dioxins, polycyclic aromatic hydrocarbons, polychlorobiphenyls, poly- and perfluoroalkyl, phthalates, parabens, organotins, and cadmium may play a role in the bone disruption. Authors searched PubMed/MEDLINE, ISI-web of knowledge, and Google scholar databases for medical subject headings terms and free-text words related to the classes mentioned above of chemicals and bone metabolism and remodeling for better clarifying and understanding the main mechanisms of bone disruption. Several EDCs act as xeno-estrogens. Considering that estrogens play a significant role in regulating bone remodeling, most of these chemicals generate hormonal imbalance with possible detrimental consequences on bone tissue structure and its mechanical and non-mechanical properties. Much evidence about bone disruptors was obtained from in vitro studies or animal models with equivocal results. Besides, a few data have been acquired from humans, and most of these data focused on the impact of EDCs on bone mineral density without considering their influence on long-term fracture risk. Moreover, humans may be exposed to a mixture of EDCs, and the final effect on bone metabolism might be attributable to either synergistic or antagonist effects. Age of first exposure, cumulative exposure over time, and the usually observed non-monotonic dose-response curve for EDCs should be considered as other essential variables influencing bone metabolism's final effect. Given these variables, observational studies are needed to analyze this issue for ecological purposes better and preserve bone health.

Sections du résumé

BACKGROUND BACKGROUND
Endocrine Disrupting Chemicals (EDCs) are ubiquitous and may significantly contribute to environmental pollution and contamination in humans and wildlife. Ecological pollutants could interfere with bone homeostasis through different mechanisms, including hormonal imbalance, direct osteoblast toxicity, and enhancement of osteoclasts activity, leading to either osteopenia or osteoporosis. Among these chemicals, bisphenols, dioxins, polycyclic aromatic hydrocarbons, polychlorobiphenyls, poly- and perfluoroalkyl, phthalates, parabens, organotins, and cadmium may play a role in the bone disruption.
METHODS METHODS
Authors searched PubMed/MEDLINE, ISI-web of knowledge, and Google scholar databases for medical subject headings terms and free-text words related to the classes mentioned above of chemicals and bone metabolism and remodeling for better clarifying and understanding the main mechanisms of bone disruption.
RESULTS RESULTS
Several EDCs act as xeno-estrogens. Considering that estrogens play a significant role in regulating bone remodeling, most of these chemicals generate hormonal imbalance with possible detrimental consequences on bone tissue structure and its mechanical and non-mechanical properties.
DISCUSSION CONCLUSIONS
Much evidence about bone disruptors was obtained from in vitro studies or animal models with equivocal results. Besides, a few data have been acquired from humans, and most of these data focused on the impact of EDCs on bone mineral density without considering their influence on long-term fracture risk. Moreover, humans may be exposed to a mixture of EDCs, and the final effect on bone metabolism might be attributable to either synergistic or antagonist effects. Age of first exposure, cumulative exposure over time, and the usually observed non-monotonic dose-response curve for EDCs should be considered as other essential variables influencing bone metabolism's final effect.
CONCLUSION CONCLUSIONS
Given these variables, observational studies are needed to analyze this issue for ecological purposes better and preserve bone health.

Identifiants

DOI: 10.2174/1871530321666210118163538 PMID: 33461478
pubmed: 33461478
pii: EMIDDT-EPUB-113401
doi: 10.2174/1871530321666210118163538
doi:

Substances chimiques

Endocrine Disruptors 0
Environmental Pollutants 0
Estrogens 0

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

704-715

Informations de copyright

Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.net.

Auteurs

Raffaele Giannattasio (R)

ASL Napoli 1 Centro, DS 29, SPS San Gennaro, Service of Endocrinology, Via San Gennaro dei Poveri 25, 80136, Naples, Italy.

Giuseppe Lisco (G)

Interdisciplinary Department of Medicine - Section of Internal Medicine, Geriatrics, Endocrinology and Rare Diseases, School of Medicine, University of Bari, Piazza Giulio Cesare 11, Policlinico of Bari, Bari, Italy.
ASL Brindisi, Unit of Endocrinology, Metabolic Disease & Clinical Nutrition, Hospital "A. Perrino", Strada 7 per Mesagne, 72100, Brindisi, Italy.

Vito Angelo Giagulli (VA)

Interdisciplinary Department of Medicine - Section of Internal Medicine, Geriatrics, Endocrinology and Rare Diseases, School of Medicine, University of Bari, Piazza Giulio Cesare 11, Policlinico of Bari, Bari, Italy.

Silvio Settembrini (S)

ASL Napoli 1 Centro, DS 26, Metabolic, Endocrine and Diabetes Unit Pellegrini Hospital, Naples, Italy.

Giovanni De Pergola (G)

Department of Biomedical Sciences and Human Oncology, Section of Internal Medicine and Clinical Oncology, University of Bari Aldo Moro, Piazza Giulio Cesare 11, 70124Bari, Italy.

Edoardo Guastamacchia (E)

Interdisciplinary Department of Medicine - Section of Internal Medicine, Geriatrics, Endocrinology and Rare Diseases, School of Medicine, University of Bari, Piazza Giulio Cesare 11, Policlinico of Bari, Bari, Italy.

Gaetano Lombardi (G)

Professor Emeritus "Federico II" University of Naples, Naples, Italy.

Vincenzo Triggiani (V)

Interdisciplinary Department of Medicine - Section of Internal Medicine, Geriatrics, Endocrinology and Rare Diseases, School of Medicine, University of Bari, Piazza Giulio Cesare 11, Policlinico of Bari, Bari, Italy.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Bone Disruption and Environmental Pollutants.
questionsmedicales.fr › Tissus › Tissu conjonctif › Os et tissu osseux › Bone Disruption and Environmental Pollutants.
questionsmedicales.fr › Actions chimiques et utilisations › Actions toxiques › Perturbateurs endocriniens › Bone Disruption and Environmental Pollutants.
questionsmedicales.fr › Actions chimiques et utilisations › Actions toxiques › Polluants environnementaux › Bone Disruption and Environmental Pollutants.
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Effets physiologiques des médicaments › Hormones, substituts d'hormones et antagonistes d'hormones › Hormones › Oestrogènes › Bone Disruption and Environmental Pollutants.
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Bone Disruption and Environmental Pollutants.