Effect of green-Mediterranean diet on intrahepatic fat: the DIRECT PLUS randomised controlled trial.
epidemiology
fatty liver
magnetic resonance imaging
nutrition
Journal
Gut
ISSN: 1468-3288
Titre abrégé: Gut
Pays: England
ID NLM: 2985108R
Informations de publication
Date de publication:
11 2021
11 2021
Historique:
received:
16
09
2020
revised:
23
11
2020
accepted:
28
11
2020
pubmed:
20
1
2021
medline:
13
1
2022
entrez:
19
1
2021
Statut:
ppublish
Résumé
To examine the effectiveness of green-Mediterranean (MED) diet, further restricted in red/processed meat, and enriched with green plants and polyphenols on non-alcoholic fatty liver disease (NAFLD), reflected by intrahepatic fat (IHF) loss. For the DIRECT-PLUS 18-month randomized clinical trial, we assigned 294 participants with abdominal obesity/dyslipidaemia into healthy dietary guidelines (HDG), MED and green-MED weight-loss diet groups, all accompanied by physical activity. Both isocaloric MED groups consumed 28 g/day walnuts (+440 mg/day polyphenols provided). The green-MED group further consumed green tea (3-4 cups/day) and Mankai (a Participants (age=51 years; 88% men; body mass index=31.3 kg/m The new suggested strategy of green-Mediterranean diet, amplified with green plant-based proteins/polyphenols as Mankai, green tea, and walnuts, and restricted in red/processed meat can double IHF loss than other healthy nutritional strategies and reduce NAFLD in half. NCT03020186.
Identifiants
pubmed: 33461965
pii: gutjnl-2020-323106
doi: 10.1136/gutjnl-2020-323106
pmc: PMC8515100
doi:
Substances chimiques
Polyphenols
0
Tea
0
Banques de données
ClinicalTrials.gov
['NCT03020186']
Types de publication
Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
2085-2095Commentaires et corrections
Type : CommentIn
Informations de copyright
© Author(s) (or their employer(s)) 2021. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.
Déclaration de conflit d'intérêts
Competing interests: IS advises to the Hinoman, Ltd. nutritional committee. Youngster is medical advisor for Mybiotix Ltd.
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