Synthetic retinoid AM80 inhibits IL-17 production of gamma delta T cells and ameliorates biliary atresia in mice.
biliary atresia
neonatal immune system
retinoids
rhesus rotavirus
virus‐induced autoimmunity
Journal
Liver international : official journal of the International Association for the Study of the Liver
ISSN: 1478-3231
Titre abrégé: Liver Int
Pays: United States
ID NLM: 101160857
Informations de publication
Date de publication:
12 2020
12 2020
Historique:
received:
29
03
2020
revised:
03
08
2020
accepted:
10
08
2020
entrez:
19
1
2021
pubmed:
20
1
2021
medline:
22
6
2021
Statut:
ppublish
Résumé
Recent evidence suggests that Interleukin (IL)-17-producing gamma delta ( Here, we established an in vitro system, enabling investigations of the effect of AM80 on the IL-17 production of AM80 efficiently reduced IL-17 production by murine Retinoids are very efficient in down-regulating IL-17 production by Biliary atresia (BA) is a rare disease which affects infants, causing progressive liver failure in most children, and is the most common indication for paediatric liver transplantation. We have previously demonstrated that IL-17, produced by
Sections du résumé
BACKGROUND & AIMS
Recent evidence suggests that Interleukin (IL)-17-producing gamma delta (
METHODS
Here, we established an in vitro system, enabling investigations of the effect of AM80 on the IL-17 production of
RESULTS
AM80 efficiently reduced IL-17 production by murine
CONCLUSIONS
Retinoids are very efficient in down-regulating IL-17 production by
LAY SUMMARY
Biliary atresia (BA) is a rare disease which affects infants, causing progressive liver failure in most children, and is the most common indication for paediatric liver transplantation. We have previously demonstrated that IL-17, produced by
Substances chimiques
Benzoates
0
Interleukin-17
0
Retinoids
0
Tetrahydronaphthalenes
0
tamibarotene
08V52GZ3H9
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
3031-3041Informations de copyright
© 2020 The Authors. Liver International published by John Wiley & Sons Ltd.
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