Immune dysregulation as a driver of idiopathic pulmonary fibrosis.
Journal
The Journal of clinical investigation
ISSN: 1558-8238
Titre abrégé: J Clin Invest
Pays: United States
ID NLM: 7802877
Informations de publication
Date de publication:
19 01 2021
19 01 2021
Historique:
entrez:
19
1
2021
pubmed:
20
1
2021
medline:
10
9
2021
Statut:
ppublish
Résumé
Idiopathic pulmonary fibrosis (IPF) affects hundreds of thousands of people worldwide, reducing their quality of life and leading to death from respiratory failure within years of diagnosis. Treatment options remain limited, with only two FDA-approved drugs available in the United States, neither of which reverse the lung damage caused by the disease or prolong the life of individuals with IPF. The only cure for IPF is lung transplantation. In this review, we discuss recent major advances in our understanding of the role of the immune system in IPF that have revealed immune dysregulation as a critical driver of disease pathophysiology. We also highlight ways in which an improved understanding of the immune system's role in IPF may enable the development of targeted immunomodulatory therapies that successfully halt or potentially even reverse lung fibrosis.
Identifiants
pubmed: 33463535
pii: 143226
doi: 10.1172/JCI143226
pmc: PMC7810481
doi:
pii:
Substances chimiques
Immunologic Factors
0
Banques de données
ClinicalTrials.gov
['NCT00125385', 'NCT03573505']
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Références
J Clin Invest. 2019 Jul 11;129(10):4091-4109
pubmed: 31295147
Am J Respir Crit Care Med. 1995 Dec;152(6 Pt 1):2163-9
pubmed: 8520791
Immunogenetics. 2012 May;64(5):371-7
pubmed: 22322675
Exp Lung Res. 1998 Nov-Dec;24(6):721-43
pubmed: 9839161
Am J Pathol. 2016 Aug;186(8):2008-2020
pubmed: 27317904
Respiration. 2007;74(2):159-69
pubmed: 17108669
Am J Respir Crit Care Med. 2013 Dec 15;188(12):1442-50
pubmed: 24070541
Am J Pathol. 1981 Oct;105(1):76-81
pubmed: 6170232
Immunity. 2015 Aug 18;43(2):382-93
pubmed: 26287683
J Immunol. 2001 Dec 1;167(11):6533-44
pubmed: 11714822
Proc Natl Acad Sci U S A. 2002 Apr 30;99(9):6292-7
pubmed: 11983918
J Immunol. 2015 Dec 1;195(11):5251-60
pubmed: 26519529
Thorax. 1995 Oct;50(10):1087-92
pubmed: 7491558
N Engl J Med. 2008 Jan 10;358(2):111-24
pubmed: 18184957
Am J Respir Crit Care Med. 2009 Jun 15;179(12):1121-30
pubmed: 19342412
Chest. 2005 Oct;128(4):2971-7
pubmed: 16236974
J Clin Med. 2016 Dec 26;6(1):
pubmed: 28035951
Int Arch Allergy Immunol. 2003 Oct;132(2):168-76
pubmed: 14600429
Int Immunopharmacol. 2007 Jul;7(7):900-11
pubmed: 17499192
Mod Pathol. 2012 Mar;25(3):416-33
pubmed: 22037258
Am J Respir Crit Care Med. 2019 May 1;199(9):1127-1138
pubmed: 30789747
Am J Respir Crit Care Med. 2001 Oct 1;164(7):1171-81
pubmed: 11673205
N Engl J Med. 2014 May 29;370(22):2083-92
pubmed: 24836312
J Clin Invest. 2015 Jul 1;125(7):2795-807
pubmed: 26098215
Respir Med Case Rep. 2018 Nov 12;26:17-22
pubmed: 30456167
Respir Res. 2018 Apr 18;19(1):66
pubmed: 29669565
Am J Respir Crit Care Med. 2008 Apr 1;177(7):771-80
pubmed: 18187693
Am J Respir Cell Mol Biol. 2002 Oct;27(4):419-27
pubmed: 12356575
J Immunol. 2003 Oct 1;171(7):3655-67
pubmed: 14500663
PLoS One. 2016 Mar 03;11(3):e0150606
pubmed: 26938654
Am J Respir Crit Care Med. 2000 Feb;161(2 Pt 1):646-64
pubmed: 10673212
J Leukoc Biol. 2008 Jun;83(6):1323-33
pubmed: 18332234
Nature. 1992 Oct 22;359(6397):693-9
pubmed: 1436033
J Immunol. 2001 Oct 15;167(8):4368-77
pubmed: 11591761
Sci Transl Med. 2013 Oct 2;5(205):205ra136
pubmed: 24089408
J Exp Med. 2017 Aug 7;214(8):2387-2404
pubmed: 28694385
Genomics. 2019 Dec;111(6):1343-1350
pubmed: 30261315
Am J Respir Crit Care Med. 2019 Jul 15;200(2):209-219
pubmed: 31051082
Am J Respir Crit Care Med. 2016 Aug 1;194(3):265-75
pubmed: 27299520
J Leukoc Biol. 2015 Aug;98(2):143-52
pubmed: 25743626
Nat Med. 2006 Aug;12(8):955-60
pubmed: 16892038
Immunity. 2004 May;20(5):623-35
pubmed: 15142530
Am J Respir Crit Care Med. 2011 Sep 1;184(5):569-81
pubmed: 21680953
J Leukoc Biol. 2000 Oct;68(4):515-21
pubmed: 11037973
Immunobiology. 2015 Nov;220(11):1284-91
pubmed: 26224246
Sci Rep. 2017 Sep 14;7(1):11586
pubmed: 28912510
Cytokine. 2014 Apr;66(2):119-26
pubmed: 24418172
Nat Rev Immunol. 2003 Jan;3(1):23-35
pubmed: 12511873
Thorax. 2017 Nov;72(11):1007-1020
pubmed: 28780502
Eur Respir J. 2016 Jul;48(1):179-86
pubmed: 27126689
Annu Rev Physiol. 2017 Feb 10;79:541-566
pubmed: 27813830
Sci Immunol. 2019 Jun 14;4(36):
pubmed: 31201259
Am J Respir Crit Care Med. 2011 Feb 15;183(4):431-40
pubmed: 20935110
Chest. 2008 Jan;133(1):226-32
pubmed: 18071016
Respir Res. 2005 Jul 24;6:81
pubmed: 16042790
Immunity. 2019 Mar 19;50(3):692-706.e7
pubmed: 30824326
Arthritis Rheum. 2008 Nov;58(11):3574-84
pubmed: 18975313
Am J Respir Cell Mol Biol. 2013 Aug;49(2):260-8
pubmed: 23526226
Am J Physiol Lung Cell Mol Physiol. 2002 Mar;282(3):L585-93
pubmed: 11839555
Respir Res. 2014 Jun 27;15:71
pubmed: 24970330
Mucosal Immunol. 2019 Jan;12(1):212-222
pubmed: 30315241
Am J Respir Crit Care Med. 2006 Apr 1;173(7):781-92
pubmed: 16415274
Nat Rev Immunol. 2014 Feb;14(2):81-93
pubmed: 24445666
Am J Respir Crit Care Med. 1999 Apr;159(4 Pt 1):1336-41
pubmed: 10194186
J Exp Med. 2010 Mar 15;207(3):535-52
pubmed: 20176803
N Engl J Med. 2014 May 29;370(22):2071-82
pubmed: 24836310
PLoS One. 2010 Oct 07;5(10):e13242
pubmed: 20949050
Proc Am Thorac Soc. 2012 Jul;9(3):111-6
pubmed: 22802283
Eur Respir Rev. 2012 Dec 1;21(126):355-61
pubmed: 23204124
Am J Respir Crit Care Med. 2014 Oct 15;190(8):906-13
pubmed: 25184687
Am J Respir Crit Care Med. 2002 Jan 15;165(2):277-304
pubmed: 11790668
Respir Res. 2019 Oct 24;20(1):232
pubmed: 31651327
Immunity. 2014 Jul 17;41(1):14-20
pubmed: 25035950
Tissue Cell. 2018 Aug;53:87-92
pubmed: 30060832
Nat Commun. 2017 Feb 23;8:14532
pubmed: 28230051
Nat Commun. 2017 Jan 27;8:14208
pubmed: 28128208
J Clin Invest. 2019 May 28;129(8):3293-3309
pubmed: 31135379
J Clin Invest. 1997 Aug 15;100(4):768-76
pubmed: 9259574
FASEB J. 2001 Nov;15(13):2545-7
pubmed: 11641263
PLoS One. 2012;7(2):e31299
pubmed: 22363610
Int J Mol Sci. 2020 Mar 25;21(7):
pubmed: 32218238
J Immunol. 1998 Feb 1;160(3):1411-8
pubmed: 9570561
Am J Respir Crit Care Med. 2016 Mar 15;193(6):614-26
pubmed: 26551758
J Exp Med. 1989 Sep 1;170(3):727-37
pubmed: 2475572
Clin Epidemiol. 2013 Nov 25;5:483-92
pubmed: 24348069
J Immunol. 2000 Jun 15;164(12):6166-73
pubmed: 10843666
PLoS One. 2015 Jan 15;10(1):e0116775
pubmed: 25590613
FASEB J. 2017 Dec;31(12):5543-5556
pubmed: 28821630
Am J Respir Cell Mol Biol. 1991 Aug;5(2):155-62
pubmed: 1892646
Am J Pathol. 2011 Oct;179(4):1733-45
pubmed: 21871427
Nat Med. 2016 Nov;22(11):1285-1293
pubmed: 27694932
Sci Transl Med. 2018 Sep 26;10(460):
pubmed: 30257954
Arthritis Rheum. 2007 Jan;56(1):323-33
pubmed: 17195236
J Exp Med. 2013 Sep 23;210(10):1977-92
pubmed: 24043763
Cytometry B Clin Cytom. 2003 Jul;54(1):19-27
pubmed: 12827664
J Clin Invest. 1999 Mar;103(6):779-88
pubmed: 10079098
Am J Respir Cell Mol Biol. 2013 Aug;49(2):167-79
pubmed: 23526222
Respir Res. 2017 Sep 8;18(1):170
pubmed: 28886713
Am J Physiol Lung Cell Mol Physiol. 2019 Mar 1;316(3):L487-L497
pubmed: 30604628
Am J Respir Crit Care Med. 2015 Jul 15;192(2):e3-19
pubmed: 26177183
Sci Transl Med. 2014 Jun 11;6(240):240ra76
pubmed: 24920662
J Immunol Res. 2019 Apr 11;2019:1845128
pubmed: 31098385
N Engl J Med. 2012 May 24;366(21):1968-77
pubmed: 22607134
Lancet Respir Med. 2014 Jul;2(7):548-56
pubmed: 24767767
Am J Respir Crit Care Med. 2018 Jan 1;197(1):94-103
pubmed: 28787186
J Clin Invest. 1991 Dec;88(6):1802-10
pubmed: 1752942
Growth Factors. 2011 Oct;29(5):196-202
pubmed: 21740331
N Engl J Med. 2007 Mar 29;356(13):1317-26
pubmed: 17392301
Am J Pathol. 1997 Mar;150(3):981-91
pubmed: 9060836
JCI Insight. 2016 Apr 7;1(4):e83116
pubmed: 27158671
Cell Commun Signal. 2018 Nov 23;16(1):89
pubmed: 30470231
J Immunol. 2013 Sep 1;191(5):2089-95
pubmed: 23872052
Immunity. 2016 Mar 15;44(3):450-462
pubmed: 26982353
Lancet Respir Med. 2013 Jun;1(4):309-317
pubmed: 24429156
PLoS One. 2017 Aug 17;12(8):e0182851
pubmed: 28817691
Lancet. 2009 Jul 18;374(9685):222-8
pubmed: 19570573
Lancet Respir Med. 2014 Jul;2(7):566-72
pubmed: 24875841
Clin Exp Immunol. 1990 Oct;82(1):133-9
pubmed: 2208788
Am J Respir Crit Care Med. 2019 Jun 15;199(12):1517-1536
pubmed: 30554520
Ann Intern Med. 2001 Jan 16;134(2):136-51
pubmed: 11177318
Am J Respir Crit Care Med. 2000 Aug;162(2 Pt 1):755-8
pubmed: 10934117
Am J Respir Crit Care Med. 2008 Nov 1;178(9):948-55
pubmed: 18669816