Globular glial tauopathy Type I presenting with behavioral variant frontotemporal dementia.
four repeat tau
frontotemporal dementia
frontotemporal lobar degeneration
globular glial tauopathy
subtype
Journal
Neuropathology : official journal of the Japanese Society of Neuropathology
ISSN: 1440-1789
Titre abrégé: Neuropathology
Pays: Australia
ID NLM: 9606526
Informations de publication
Date de publication:
Oct 2020
Oct 2020
Historique:
received:
06
11
2019
revised:
24
12
2019
accepted:
15
01
2020
entrez:
19
1
2021
pubmed:
20
1
2021
medline:
19
8
2021
Statut:
ppublish
Résumé
Globular glial tauopathy (GGT) is a recently proposed tauopathy characterized by the globular accumulation of four-repeat (4R) tau in the oligodendroglia (globular oligodendroglial inclusion (GOI)) and astrocytes (globular astrocytic inclusion (GAI)), in addition to deposition in neurons. Although it is proposed that GGT should be classified into three different neuropathological subtypes, previous reports have indicated that subclassification might be difficult in some cases. We report an autopy case of a 79-year-old man with behavioral variant frontotemporal dementia (bvFTD). He developed behavioral changes at 67 years of age and had auditory hallucinations and persecutory delusions at admission to a psychiatric hospital at 69 years of age. Neuropathologically, marked atrophy of the frontotemporal lobes and severe degeneration of the white matter and frontopontine tract were observed. The present case corresponded to GGT Type I, as numerous GOIs were observed, predominantly in the frontotemporal region. However, concurrent degeneration of the motor cortex and corticospinal tract suggest characteristics of Type II. Although the relationship between psychotic symptoms and GGT remains unclear, the present case demonstrates heterogeneity of GGT subtypes.
Substances chimiques
tau Proteins
0
Types de publication
Case Reports
Langues
eng
Sous-ensembles de citation
IM
Pagination
515-525Subventions
Organisme : Grants-in Aid from the Research Committee of CNS Degenerative Diseases, Research on Policy Planning and Evaluation for Rare and Intractable Diseases, Health, Labour and Welfare Sciences Research Grants, the Ministry of Health, Labour and Welfare, Japan
Organisme : Ministry of Health, Labour and Welfare, Japan
Organisme : Japan Agency for Medical Research and Development
ID : JP18dm0107105
Organisme : Japan Agency for Medical Research and Development
ID : JP19dm0107108h
Organisme : Japan Agency for Medical Research and Development
ID : JP19ek0109391
Organisme : Japan Agency for Medical Research and Development
ID : JP19ek0109392
Organisme : Japan Agency for Medical Research and Development
ID : JP19kk0205022
Organisme : Japan Society for the Promotion of Science
ID : JP17K10294
Organisme : Japan Society for the Promotion of Science
ID : JP19K17059
Informations de copyright
© 2020 Japanese Society of Neuropathology.
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