Stress-Induced Hyperglycaemia in Non-Diabetic Patients with Acute Coronary Syndrome: From Molecular Mechanisms to New Therapeutic Perspectives.
Acute Coronary Syndrome
/ complications
Adrenergic beta-Antagonists
/ therapeutic use
Angiotensin-Converting Enzyme Inhibitors
/ therapeutic use
Animals
Dipeptidyl-Peptidase IV Inhibitors
/ therapeutic use
Glucagon-Like Peptide-1 Receptor
/ agonists
Humans
Hyperglycemia
/ drug therapy
Hypoglycemic Agents
/ therapeutic use
Insulin
/ therapeutic use
Molecular Targeted Therapy
Stress, Psychological
/ complications
DPP-4 inhibitors
GLP-1 receptor agonist
acute coronary syndrome
glifozins
insulin
multitargeted therapeutic strategy
non-diabetic patient
stress-induced hyperglycaemia
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
14 Jan 2021
14 Jan 2021
Historique:
received:
10
12
2020
revised:
08
01
2021
accepted:
10
01
2021
entrez:
20
1
2021
pubmed:
21
1
2021
medline:
10
9
2021
Statut:
epublish
Résumé
Stress-induced hyperglycaemia (SIH) at hospital admission for acute coronary syndrome is associated with poor outcome, especially in patients without known diabetes. Nevertheless, insulin treatment in these subjects was not correlated with the reduction of mortality. This is likely due to the fact that SIH in the context of an acute coronary syndrome, compared to that in known diabetes, represents an epiphenomenon of other pathological conditions, such as adrenergic and renin-angiotensin system over-activity, hyperglucagonaemia, increase of circulating free fatty acids and pancreatic beta-cell dysfunction, which are not completely reversed by insulin therapy and so worsen the prognosis. Thus, SIH may be considered not only as a biomarker of organ damage, but also as an indicator of a more complex therapeutic strategy in these subjects. The aim of this review is to analyse the molecular mechanisms by which SIH may favour a worse prognosis in non-diabetic patients with acute coronary syndrome and identify new therapeutic strategies, in addition to insulin therapy, for a more appropriate treatment and improved outcomes.
Identifiants
pubmed: 33466656
pii: ijms22020775
doi: 10.3390/ijms22020775
pmc: PMC7828822
pii:
doi:
Substances chimiques
Adrenergic beta-Antagonists
0
Angiotensin-Converting Enzyme Inhibitors
0
Dipeptidyl-Peptidase IV Inhibitors
0
Glucagon-Like Peptide-1 Receptor
0
Hypoglycemic Agents
0
Insulin
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Références
J Am Coll Cardiol. 2002 Nov 20;40(10):1748-54
pubmed: 12446057
Diabetologia. 2005 Nov;48(11):2229-35
pubmed: 16143862
Diabetes Care. 2012 Jan;35(1):19-24
pubmed: 22074724
Eur Heart J. 2005 Jul;26(13):1255-61
pubmed: 15821004
J Intensive Care Med. 2009 Sep-Oct;24(5):293-316
pubmed: 19703817
Circulation. 2002 Oct 15;106(16):2067-72
pubmed: 12379575
Diabetes Care. 2006 Apr;29(4):765-70
pubmed: 16567812
Ann Intern Med. 1995 Jan 15;122(2):133-41
pubmed: 7992988
J Am Coll Cardiol. 2006 Apr 18;47(8):1730-1
pubmed: 16631017
Diabetes Obes Metab. 2013 Feb;15(2):144-52
pubmed: 22950668
Cardiovasc Res. 2007 Dec 1;76(3):453-64
pubmed: 17698050
Lancet. 2019 Jan 5;393(10166):31-39
pubmed: 30424892
Metabolism. 1989 Dec;38(12):1162-3
pubmed: 2593829
Cardiovasc Diabetol. 2018 Nov 29;17(1):152
pubmed: 30497513
J Pharmacol Exp Ther. 1995 Sep;274(3):1067-71
pubmed: 7562470
Eur Heart J. 2018 Jan 7;39(2):119-177
pubmed: 28886621
Circulation. 2019 May 28;139(22):2516-2527
pubmed: 30882239
Diabete Metab. 1975 Sep;1(3):201-8
pubmed: 791728
Arterioscler Thromb Vasc Biol. 2013 Sep;33(9):2252-60
pubmed: 23868944
J Clin Endocrinol Metab. 2012 Aug;97(8):2862-71
pubmed: 22639289
Eur Heart J. 2010 Jul;31(13):1557-64
pubmed: 20519242
J Clin Invest. 2007 Apr;117(4):910-8
pubmed: 17404617
Diabetes. 2004 Apr;53(4):989-97
pubmed: 15047614
J Intern Med. 2004 Oct;256(4):288-97
pubmed: 15367171
Lancet. 2007 Jan 20;369(9557):201-7
pubmed: 17240286
Lipids. 2011 Mar;46(3):209-28
pubmed: 21308420
Arterioscler Thromb Vasc Biol. 2005 Jun;25(6):1142-7
pubmed: 15802620
Metabolism. 2006 Sep;55(9):1177-85
pubmed: 16919536
N Engl J Med. 2019 Feb 7;380(6):539-548
pubmed: 30415601
Eur Heart J. 2020 Aug 29;:
pubmed: 32860058
Am J Cardiol. 2007 Apr 1;99(7):1006-12
pubmed: 17398202
Br Heart J. 1978 Feb;40(2):117-23
pubmed: 637962
J Am Coll Cardiol. 2009 Feb 10;53(6):501-10
pubmed: 19195607
Lancet. 2015 May 23;385(9982):2067-76
pubmed: 25765696
J Clin Endocrinol Metab. 2000 Aug;85(8):2970-3
pubmed: 10946914
Am Heart J. 2015 Nov;170(5):845-54
pubmed: 26542491
Int J Cardiol. 2013 Oct 9;168(4):3954-62
pubmed: 23876463
JAMA. 2004 Nov 10;292(18):2227-36
pubmed: 15536109
Nature. 1975 Feb 27;253(5494):746-7
pubmed: 1113869
Eur Heart J. 2020 Jan 7;41(2):255-323
pubmed: 31497854
Lancet. 2018 Oct 27;392(10157):1519-1529
pubmed: 30291013
JAMA. 2007 Nov 28;298(20):2399-405
pubmed: 18042917
Eur Heart J. 2005 Feb;26(4):328-31
pubmed: 15618047
JAMA Cardiol. 2020 Jun 17;:
pubmed: 32584928
Diabetes Care. 2005 Sep;28(9):2261-6
pubmed: 16123505
Diabetes. 1999 Dec;48(12):2270-6
pubmed: 10580413
Diabetes. 2002 Apr;51(4):1076-82
pubmed: 11916928
Am Heart J. 1999 Jun;137(6):1145-52
pubmed: 10347344
Eur Heart J. 2006 Jun;27(11):1289-97
pubmed: 16611669
Int J Mol Sci. 2019 Mar 30;20(7):
pubmed: 30935055
Lancet. 1974 Feb 23;1(7852):284-8
pubmed: 4130473
Eur Heart J. 2005 Apr;26(7):650-61
pubmed: 15728645
Am J Med. 2011 Aug;124(8):724-30
pubmed: 21787901
Am Heart J. 1981 Dec;102(6 Pt 1):1038-49
pubmed: 7032266
J Am Coll Cardiol. 2003 Sep 3;42(5):784-91
pubmed: 12957421
Diabetes Care. 2014 Oct;37(10):2763-73
pubmed: 25011946
Hypertension. 2002 Dec;40(6):872-9
pubmed: 12468572
Am J Cardiol. 2011 Jun 15;107(12):1772-8
pubmed: 21529724
Circ Res. 2004 May 14;94(9):1211-8
pubmed: 15044323
Circ J. 2006 Nov;70(11):1509-14
pubmed: 17062979
Lancet. 1969 Dec 6;2(7632):1209-13
pubmed: 4187809
Diabetes. 1995 Aug;44(8):924-8
pubmed: 7621998
J Cardiovasc Pharmacol. 2006 Jul;48(1):862-9
pubmed: 16891916
J Diabetes Sci Technol. 2010 Nov 01;4(6):1338-44
pubmed: 21129328
Free Radic Biol Med. 2017 Mar;104:298-310
pubmed: 28132924
JAMA Intern Med. 2013 Nov 11;173(20):1896-904
pubmed: 24018647
Diabetologia. 1988 Dec;31(12):889-91
pubmed: 3240844
Heart. 2012 Aug;98(16):1189-91
pubmed: 22735684
N Engl J Med. 2016 Nov 10;375(19):1834-1844
pubmed: 27633186
Diabetes Ther. 2017 Aug;8(4):821-827
pubmed: 28646412
Arch Intern Med. 2009 Feb 23;169(4):402-9
pubmed: 19237725
Lancet. 2000 Mar 4;355(9206):773-8
pubmed: 10711923
J Clin Invest. 1998 May 1;101(9):1905-15
pubmed: 9576755
Am J Med. 2002 Mar;112(4):305-11
pubmed: 11893370
Am J Physiol Heart Circ Physiol. 2001 Nov;281(5):H2097-104
pubmed: 11668071
Circulation. 2001 May 22;103(20):2441-6
pubmed: 11369683
Arterioscler Thromb Vasc Biol. 2007 May;27(5):1213-9
pubmed: 17347481
Circulation. 2014 Oct 28;130(18):1579-88
pubmed: 25189213
Circulation. 1990 Sep;82(3 Suppl):II13-22
pubmed: 2203558
J Am Coll Cardiol. 2009 Apr 21;53(16):1425-36
pubmed: 19371826
Lancet. 1983 Aug 20;2(8347):419-22
pubmed: 6135910
Diabetes Obes Metab. 2011 Apr;13(4):302-12
pubmed: 21205117
Diabetol Metab Syndr. 2017 Jul 17;9:54
pubmed: 28725273
Eur Heart J Acute Cardiovasc Care. 2017 Dec;6(8):738-743
pubmed: 27037239
Circ Cardiovasc Imaging. 2016 Dec;9(12):
pubmed: 27940956
Diabetes. 2010 Nov;59(11):2936-40
pubmed: 20811038
J Biol Chem. 2000 Jun 9;275(23):17728-39
pubmed: 10837498
Endocrine. 2016 Jun;52(3):516-26
pubmed: 26573925
Cell Metab. 2018 Apr 3;27(4):740-756
pubmed: 29617641
J Am Coll Cardiol. 2005 Sep 6;46(5):821-6
pubmed: 16139131
Diabetes Res Clin Pract. 2011 May;92(2):213-22
pubmed: 21345512
J Clin Invest. 1971 Sep;50(9):1869-73
pubmed: 5564394
Endocr Rev. 2007 Feb;28(1):84-116
pubmed: 17261637
Lancet. 2004 Jun 19;363(9426):2022-31
pubmed: 15207952
Scand J Clin Lab Invest. 1971 Dec;28(4):389-93
pubmed: 5157041
N Engl J Med. 2015 Nov 26;373(22):2117-28
pubmed: 26378978
Circulation. 1996 Jun 1;93(11):1963-9
pubmed: 8640969
Eur Heart J. 2016 Nov 07;37(42):3192-3200
pubmed: 27153861
Circ Cardiovasc Imaging. 2014 Mar;7(2):274-81
pubmed: 24503784
Am J Cardiol. 2007 Dec 1;100(11):1614-8
pubmed: 18036357
J Pharmacol Exp Ther. 2006 Jun;317(3):1106-13
pubmed: 16489128
J Am Coll Cardiol. 2020 Mar 17;75(10):1128-1141
pubmed: 32164886
Diabetes. 1996 Jul;45(7):954-9
pubmed: 8666148
Am Heart J. 2020 Mar;221:39-47
pubmed: 31901799
Diabetes Metab. 2012 Apr;38(2):113-27
pubmed: 22209680
Diabetes Care. 2020 Sep;43(9):2303-2312
pubmed: 32910778
Mol Cell Biochem. 1998 May;182(1-2):101-8
pubmed: 9609119
JAMA. 2012 May 9;307(18):1925-33
pubmed: 22452807
J Am Coll Cardiol. 2003 Jan 1;41(1):1-7
pubmed: 12570936
Cardiovasc Res. 2001 Dec;52(3):361-71
pubmed: 11738053
Diabetes. 2006 Jun;55(6):1695-704
pubmed: 16731832
Br J Pharmacol. 2001 Aug;133(8):1330-8
pubmed: 11498519
Am J Cardiol. 1990 May 22;65(19):28I-31I
pubmed: 2140009
JAMA. 2006 Apr 12;295(14):1681-7
pubmed: 16609090
Am J Clin Nutr. 2004 Jul;80(1):51-7
pubmed: 15213027
Circulation. 2018 Dec 18;138(25):2884-2894
pubmed: 30566004
Diabetes. 2006 Jan;55(1):136-40
pubmed: 16380486
Cardiovasc Diabetol. 2020 Jun 15;19(1):91
pubmed: 32539724
Circ Res. 2005 Feb 4;96(2):180-8
pubmed: 15591229
Diabetes. 2002 Apr;51(4):958-65
pubmed: 11916913
J Cardiol. 2014 Apr;63(4):274-80
pubmed: 24145196
BMJ. 1997 May 24;314(7093):1512-5
pubmed: 9169397
Mol Metab. 2020 Oct 14;:101102
pubmed: 33068776
Biochem Biophys Res Commun. 2010 Jan 15;391(3):1405-8
pubmed: 20026306
JAMA. 2009 Apr 15;301(15):1556-64
pubmed: 19366775
J Am Coll Cardiol. 1999 Jul;34(1):146-54
pubmed: 10400004
Circ Res. 2010 Oct 29;107(9):1058-70
pubmed: 21030723
N Engl J Med. 1981 Jun 18;304(25):1518-24
pubmed: 7015132
Circulation. 1998 Nov 24;98(21):2227-34
pubmed: 9867443
Mol Cell Biochem. 2000 Dec;215(1-2):145-52
pubmed: 11204450
Circulation. 2019 Nov 12;140(20):1613-1622
pubmed: 31542942
Dig Dis Sci. 1993 Apr;38(4):665-73
pubmed: 8462365
Am J Cardiol. 2007 Jun 4;99(11A):12H-18H
pubmed: 17665748
Circulation. 2004 Mar 2;109(8):962-5
pubmed: 14981009
Am J Med. 1974 Nov;57(5):747-52
pubmed: 4440699
Lancet Diabetes Endocrinol. 2019 Oct;7(10):776-785
pubmed: 31422062
Diabetes. 2012 Nov;61(11):2993-7
pubmed: 22891214
Am J Physiol Heart Circ Physiol. 2004 May;286(5):H1597-602
pubmed: 15072967
Diabetes Obes Metab. 2003 Jul;5(4):214-22
pubmed: 12795654
N Engl J Med. 2012 Sep 20;367(12):1108-18
pubmed: 22992074
J Clin Endocrinol Metab. 2015 Aug;100(8):2987-95
pubmed: 26079776
JAMA. 2005 Feb 23;293(8):979-86
pubmed: 15728169
Circulation. 2008 May 20;117(20):2706-15; discussion 2715
pubmed: 18490538
Trends Cardiovasc Med. 2006 Aug;16(6):183-8
pubmed: 16839860
J Diabetes Sci Technol. 2009 Nov 01;3(6):1292-301
pubmed: 20144383
Lancet. 2009 May 23;373(9677):1765-72
pubmed: 19465231
Circulation. 1999 May 25;99(20):2626-32
pubmed: 10338454
Diabetes Obes Metab. 2020 Mar;22(3):442-451
pubmed: 31903692
Circulation. 2007 Sep 4;116(10):1170-5
pubmed: 17698735
Arterioscler Thromb Vasc Biol. 2010 Dec;30(12):2487-94
pubmed: 20705919
Circulation. 2019 Nov 19;140(21):1693-1702
pubmed: 31434508
Eur Heart J. 2006 Dec;27(24):2969-74
pubmed: 17090612
N Engl J Med. 2016 Jul 28;375(4):311-22
pubmed: 27295427
JAMA. 2005 Jan 26;293(4):437-46
pubmed: 15671428
JAMA. 2001 Oct 17;286(15):1882-5
pubmed: 11597291
Diabetes Obes Metab. 2018 Dec;20(12):2911-2918
pubmed: 30033664
Lancet. 2005 Nov 5;366(9497):1622-32
pubmed: 16271643
J Hypertens. 2006 Mar;24(3):591-6
pubmed: 16467663
Endocrinology. 2003 Dec;144(12):5149-58
pubmed: 12960095
N Engl J Med. 2014 Sep 11;371(11):993-1004
pubmed: 25176015
J Clin Med. 2020 Jul 07;9(7):
pubmed: 32646007
N Engl J Med. 1981 Jun 25;304(26):1575-80
pubmed: 7015135
Circulation. 2005 Jun 14;111(23):3078-86
pubmed: 15939812
Diabetologia. 1997 Jan;40(1):23-9
pubmed: 9028714
J Hypertens. 2001 Aug;19(8):1429-35
pubmed: 11518851
J Am Coll Cardiol. 2005 Apr 5;45(7):999-1002
pubmed: 15808754
Circulation. 2019 Mar 12;139(11):1384-1395
pubmed: 30586757
Lancet. 2009 May 23;373(9677):1798-807
pubmed: 19465235
Lancet Diabetes Endocrinol. 2014 Aug;2(8):627-33
pubmed: 24831989
Adv Pharmacol. 2005;52:151-71
pubmed: 16492545
J Intern Med. 2013 Apr;273(4):410-21
pubmed: 23331339
J Clin Endocrinol Metab. 1981 Jun;52(6):1235-41
pubmed: 7014600
Curr Atheroscler Rep. 2010 Nov;12(6):391-6
pubmed: 20725810
J Diabetes Complications. 2017 Feb;31(2):295-303
pubmed: 27771154
J Biol Chem. 1999 Dec 3;274(49):34795-802
pubmed: 10574950
Diabetologia. 2016 Jul;59(7):1333-1339
pubmed: 27112340
Crit Care Med. 2012 Dec;40(12):3251-76
pubmed: 23164767
JAMA Cardiol. 2016 May 1;1(2):126-35
pubmed: 27437883
Circulation. 2017 Aug 29;136(9):849-870
pubmed: 28847797
Curr Heart Fail Rep. 2017 Aug;14(4):275-283
pubmed: 28647919
J Endocrinol. 2018 Feb;236(2):69-84
pubmed: 29142025
Diabetes Care. 2013 Aug;36(8):2346-50
pubmed: 23564922
Mol Cell Biochem. 2004 May;260(1-2):153-9
pubmed: 15228097
Diabetes Metab J. 2020 May 28;:
pubmed: 32602273
Diabetes. 1996 Apr;45(4):471-7
pubmed: 8603769
JAMA Cardiol. 2017 Sep 1;2(9):939-940
pubmed: 28636701
Diabetologia. 2009 Nov;52(11):2288-98
pubmed: 19655124
Am J Cardiol. 2020 Mar 15;125(6):851-859
pubmed: 31964502
J Clin Med. 2019 Jul 21;8(7):
pubmed: 31330868
Regul Pept. 2005 Feb 15;125(1-3):173-7
pubmed: 15582729
Am J Hypertens. 2005 Dec;18(12 Pt 2):169S-176S
pubmed: 16373195
Diabetes Care. 1999 Nov;22(11):1827-31
pubmed: 10546015
Eur Heart J. 2012 Jun;33(12):1491-9
pubmed: 21920963
Diabetologia. 2017 Feb;60(2):215-225
pubmed: 27878313
J Diabetes Complications. 2007 Sep-Oct;21(5):294-9
pubmed: 17825753
Acta Diabetol. 2001;38(2):71-6
pubmed: 11757804
J Clin Invest. 1974 Aug;54(2):278-86
pubmed: 4847245
J Am Coll Cardiol. 2008 Jan 15;51(2):93-102
pubmed: 18191731
J Clin Endocrinol Metab. 2012 Mar;97(3):933-42
pubmed: 22170713
Diabetes Metab Res Rev. 2008 Jul-Aug;24(5):353-63
pubmed: 18461635
Am J Physiol. 1998 Aug;275(2):H721-5
pubmed: 9683464
Diabetes Care. 2020 Jan;43(Suppl 1):S111-S134
pubmed: 31862753
Eur Heart J. 2020 Feb 14;41(7):882-889
pubmed: 31620788
Lancet. 1994 Jan 15;343(8890):155-8
pubmed: 7904009
Eur Heart J. 2016 May 14;37(19):1526-34
pubmed: 26819227
Circ Res. 2008 Feb 29;102(4):401-14
pubmed: 18309108