Grafting of 18β-Glycyrrhetinic Acid and Sialic Acid onto Chitosan to Produce a New Amphipathic Chitosan Derivative: Synthesis, Characterization, and Cytotoxicity.
18β-glycyrrhetinic acid
chitosan
chitosan derivatives
cytotoxicity
sialic acid
Journal
Molecules (Basel, Switzerland)
ISSN: 1420-3049
Titre abrégé: Molecules
Pays: Switzerland
ID NLM: 100964009
Informations de publication
Date de publication:
16 Jan 2021
16 Jan 2021
Historique:
received:
19
12
2020
revised:
08
01
2021
accepted:
14
01
2021
entrez:
20
1
2021
pubmed:
21
1
2021
medline:
10
4
2021
Statut:
epublish
Résumé
Chitosan is the only cationic polysaccharide found in nature. It has broad application prospects in biomaterials, but its application is limited due to its poor solubility in water. A novel chitosan derivative was synthesized by amidation of chitosan with 18β-glycyrrhetinic acid and sialic acid. The chitosan derivatives were characterized by Fourier transform infrared spectroscopy, thermogravimetric analysis, and measurement of the zeta potential. We also investigated the solubility, cytotoxicity, and blood compatibility of chitosan derivatives. 18β-glycyrrhetinic acid and sialic acid could be grafted onto chitosan molecular chains. The thermal stability of the synthesized chitosan derivatives was decreased and the surface was positively charged in water and phosphate-buffered saline. After chitosan had been modified by 18 β-glycyrrhetinic acid and sialic acid, the solubility of chitosan was improved greatly in water and phosphate-buffered saline, and percent hemolysis was <5%. Novel amphiphilic chitosan derivatives could be suitable polymers for biomedical purposes.
Identifiants
pubmed: 33467083
pii: molecules26020452
doi: 10.3390/molecules26020452
pmc: PMC7829902
pii:
doi:
Substances chimiques
18alpha-glycyrrhetinic acid
1449-05-4
Chitosan
9012-76-4
N-Acetylneuraminic Acid
GZP2782OP0
Glycyrrhetinic Acid
P540XA09DR
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
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