Regulation of Decay Accelerating Factor Primes Human Germinal Center B Cells for Phagocytosis.
complement regulating proteins
complement-mediated phagocytosis
decay accelerating factor (DAF)
germinal center (GC)
human B cell development
Journal
Frontiers in immunology
ISSN: 1664-3224
Titre abrégé: Front Immunol
Pays: Switzerland
ID NLM: 101560960
Informations de publication
Date de publication:
2020
2020
Historique:
received:
27
08
2020
accepted:
13
11
2020
entrez:
20
1
2021
pubmed:
21
1
2021
medline:
17
6
2021
Statut:
epublish
Résumé
Germinal centers (GC) are sites for extensive B cell proliferation and homeostasis is maintained by programmed cell death. The complement regulatory protein Decay Accelerating Factor (DAF) blocks complement deposition on host cells and therefore also phagocytosis of cells. Here, we show that B cells downregulate DAF upon BCR engagement and that T cell-dependent stimuli preferentially led to activation of DAF
Identifiants
pubmed: 33469456
doi: 10.3389/fimmu.2020.599647
pmc: PMC7813799
doi:
Substances chimiques
CD55 Antigens
0
PRDM1 protein, human
138415-26-6
Positive Regulatory Domain I-Binding Factor 1
EC 2.1.1.-
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
599647Subventions
Organisme : NIAID NIH HHS
ID : U19 AI142777
Pays : United States
Informations de copyright
Copyright © 2021 Dernstedt, Leidig, Holm, Kerkman, Mjösberg, Ahlm, Henriksson, Hultdin and Forsell.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
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