Whole blood interleukin-2 release test to detect and characterize rare circulating gluten-specific T cell responses in coeliac disease.
Adult
Aged
Celiac Disease
/ immunology
Chemokine CXCL10
/ immunology
Cytokines
/ immunology
Epitopes, T-Lymphocyte
/ immunology
Female
Gliadin
/ immunology
Glutens
/ immunology
HLA-DQ Antigens
/ immunology
Humans
Immunity, Cellular
/ immunology
Interferon-gamma
/ immunology
Interleukin-2
/ immunology
Interleukin-8
/ immunology
Male
Middle Aged
Peptide Fragments
/ immunology
Peptides
/ immunology
T-Lymphocytes
/ immunology
Young Adult
IL-2
T cells
coeliac disease
cytokine release assay
cytokines
diagnosis
Journal
Clinical and experimental immunology
ISSN: 1365-2249
Titre abrégé: Clin Exp Immunol
Pays: England
ID NLM: 0057202
Informations de publication
Date de publication:
06 2021
06 2021
Historique:
revised:
01
01
2021
received:
05
11
2020
accepted:
04
01
2021
pubmed:
21
1
2021
medline:
15
12
2021
entrez:
20
1
2021
Statut:
ppublish
Résumé
Whole blood cytokine release assays (CRA) assessing cellular immunity to gluten could simplify the diagnosis and monitoring of coeliac disease (CD). We aimed to determine the effectiveness of electrochemiluminescence CRA to detect responses to immunodominant gliadin peptides. HLA-DQ2·5
Identifiants
pubmed: 33469922
doi: 10.1111/cei.13578
pmc: PMC8119810
doi:
Substances chimiques
Chemokine CXCL10
0
Cytokines
0
Epitopes, T-Lymphocyte
0
HLA-DQ Antigens
0
HLA-DQ2 antigen
0
Interleukin-2
0
Interleukin-8
0
Peptide Fragments
0
Peptides
0
Glutens
8002-80-0
Interferon-gamma
82115-62-6
Gliadin
9007-90-3
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
321-334Subventions
Organisme : ImmusanT, Inc.
Informations de copyright
© 2021 British Society for Immunology.
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