Peripherally misfolded proteins exacerbate ischemic stroke-induced neuroinflammation and brain injury.
Brain
Crosstalk
Exosome
Heart
Ischemia
Neuroinflammation
Peripheral
Protein aggregation
Stroke
Journal
Journal of neuroinflammation
ISSN: 1742-2094
Titre abrégé: J Neuroinflammation
Pays: England
ID NLM: 101222974
Informations de publication
Date de publication:
20 Jan 2021
20 Jan 2021
Historique:
received:
23
06
2020
accepted:
11
01
2021
entrez:
21
1
2021
pubmed:
22
1
2021
medline:
14
10
2021
Statut:
epublish
Résumé
Protein aggregates can be found in peripheral organs, such as the heart, kidney, and pancreas, but little is known about the impact of peripherally misfolded proteins on neuroinflammation and brain functional recovery following ischemic stroke. Here, we studied the ischemia/reperfusion (I/R) induced brain injury in mice with cardiomyocyte-restricted overexpression of a missense (R120G) mutant small heat shock protein, αB-crystallin (CryAB Our results showed that CryAB These results suggest that peripherally misfolded proteins in the heart remotely enhance neuroinflammation and exacerbate brain injury following I/R likely through exosomes, which may represent an underappreciated mechanism underlying heart-brain crosstalk.
Sections du résumé
BACKGROUND
BACKGROUND
Protein aggregates can be found in peripheral organs, such as the heart, kidney, and pancreas, but little is known about the impact of peripherally misfolded proteins on neuroinflammation and brain functional recovery following ischemic stroke.
METHODS
METHODS
Here, we studied the ischemia/reperfusion (I/R) induced brain injury in mice with cardiomyocyte-restricted overexpression of a missense (R120G) mutant small heat shock protein, αB-crystallin (CryAB
RESULTS
RESULTS
Our results showed that CryAB
CONCLUSIONS
CONCLUSIONS
These results suggest that peripherally misfolded proteins in the heart remotely enhance neuroinflammation and exacerbate brain injury following I/R likely through exosomes, which may represent an underappreciated mechanism underlying heart-brain crosstalk.
Identifiants
pubmed: 33472658
doi: 10.1186/s12974-021-02081-7
pii: 10.1186/s12974-021-02081-7
pmc: PMC7818745
doi:
Substances chimiques
Cryab protein, mouse
0
alpha-Crystallin B Chain
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
29Subventions
Organisme : NINDS NIH HHS
ID : NS088084
Pays : United States
Organisme : NHLBI NIH HHS
ID : HL131667
Pays : United States
Organisme : NIH HHS
ID : P20GM103443
Pays : United States
Organisme : NIGMS NIH HHS
ID : T32 GM136503
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL153614
Pays : United States
Organisme : NHLBI NIH HHS
ID : HL072166
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL072166
Pays : United States
Organisme : NIGMS NIH HHS
ID : P20 GM103443
Pays : United States
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