Preparation and Monitoring of Small Animals in Renal MRI.


Journal

Methods in molecular biology (Clifton, N.J.)
ISSN: 1940-6029
Titre abrégé: Methods Mol Biol
Pays: United States
ID NLM: 9214969

Informations de publication

Date de publication:
2021
Historique:
entrez: 21 1 2021
pubmed: 22 1 2021
medline: 27 3 2021
Statut: ppublish

Résumé

Renal diseases remain devastating illnesses with unacceptably high rates of mortality and morbidity worldwide. Animal models are essential tools to better understand the pathomechanism of kidney-related illnesses and to develop new, successful therapeutic strategies. Magnetic resonance imaging (MRI) has been actively explored in the last decades for assessing renal function, perfusion, tissue oxygenation as well as the degree of fibrosis and inflammation. This chapter aims to provide an overview of the preparation and monitoring of small animals before, during, and after surgical interventions or MR imaging. Standardization of experimental settings such as body temperature or hydration of animals and minimizing pain and distress are essential for diminishing nonexperimental variables as well as for conducting ethical research.This publication is based upon work from the COST Action PARENCHIMA, a community-driven network funded by the European Cooperation in Science and Technology (COST) program of the European Union, which aims to improve the reproducibility and standardization of renal MRI biomarkers.

Identifiants

pubmed: 33475993
doi: 10.1007/978-1-0716-0978-1_3
pmc: PMC9703213
doi:

Substances chimiques

Biomarkers 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

45-55

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Auteurs

Tamas Kaucsar (T)

1st Department of Pediatrics, Semmelweis University, Budapest, Hungary.

Adam Hosszu (A)

1st Department of Pediatrics, Semmelweis University, Budapest, Hungary.

Erdmann Seeliger (E)

Working Group Integrative Kidney Physiology, Institute of Physiology, Charité-University Medicine Berlin, Berlin, Germany.

Henning M Reimann (HM)

Berlin Ultrahigh Field Facility (B.U.F.F.), Max Delbrück Center for Molecular Medicine, Berlin, Germany.

Andrea Fekete (A)

1st Department of Pediatrics, Semmelweis University, Budapest, Hungary. andrea.fekete@gmail.com.

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Classifications MeSH