Discovery of Natural Inhibitors of Cholinesterases from
Acetylcholinesterase
/ metabolism
Alzheimer Disease
/ enzymology
Amyloid beta-Peptides
/ metabolism
Binding Sites
Butyrylcholinesterase
/ metabolism
Cholinesterase Inhibitors
/ chemistry
Humans
Hydrangea
/ chemistry
Hydrophobic and Hydrophilic Interactions
Isocoumarins
Kinetics
Molecular Docking Simulation
Plant Extracts
/ chemistry
Structure-Activity Relationship
Alzheimer’s disease (AD)
cholinesterase
hydrangenol 8-O-glucoside pentaacetate
molecular docking
thunberginol C
Journal
Nutrients
ISSN: 2072-6643
Titre abrégé: Nutrients
Pays: Switzerland
ID NLM: 101521595
Informations de publication
Date de publication:
17 Jan 2021
17 Jan 2021
Historique:
received:
27
11
2020
revised:
11
01
2021
accepted:
14
01
2021
entrez:
22
1
2021
pubmed:
23
1
2021
medline:
28
4
2021
Statut:
epublish
Résumé
Alzheimer's disease (AD) is a neurodegenerative disease conceptualized as a clinical-biological neurodegenerative construct where amyloid-beta pathophysiology is supposed to play a role. The loss of cognitive functions is mostly characterized by the rapid hydrolysis of acetylcholine by cholinesterases including acetylcholinesterase (AChE) and butyrylcholinesterase (BChE). Moreover, both enzymes are responsible for non-catalytic actions such as interacting with amyloid β peptide (Aβ) which further leads to promote senile plaque formation. In searching for a natural cholinesterase inhibitor, the present study focused on two isocoumarines from hydrangea, thunberginol C (TC) and hydrangenol 8-
Identifiants
pubmed: 33477276
pii: nu13010254
doi: 10.3390/nu13010254
pmc: PMC7830924
pii:
doi:
Substances chimiques
Amyloid beta-Peptides
0
Cholinesterase Inhibitors
0
Isocoumarins
0
Plant Extracts
0
Acetylcholinesterase
EC 3.1.1.7
Butyrylcholinesterase
EC 3.1.1.8
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Dong-A University
ID : Not applicable
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