Cold-Active β-Galactosidases: Insight into Cold Adaption Mechanisms and Biotechnological Exploitation.
GH1
GH2
GH35
GH42
galacto-oligosaccharides
lactose hydrolysis
psychrophilic enzymes
Journal
Marine drugs
ISSN: 1660-3397
Titre abrégé: Mar Drugs
Pays: Switzerland
ID NLM: 101213729
Informations de publication
Date de publication:
19 Jan 2021
19 Jan 2021
Historique:
received:
14
12
2020
revised:
12
01
2021
accepted:
15
01
2021
entrez:
22
1
2021
pubmed:
23
1
2021
medline:
15
5
2021
Statut:
epublish
Résumé
β-galactosidases (EC 3.2.1.23) catalyze the hydrolysis of β-galactosidic bonds in oligosaccharides and, under certain conditions, transfer a sugar moiety from a glycosyl donor to an acceptor. Cold-active β-galactosidases are identified in microorganisms endemic to permanently low-temperature environments. While mesophilic β-galactosidases are broadly studied and employed for biotechnological purposes, the cold-active enzymes are still scarcely explored, although they may prove very useful in biotechnological processes at low temperature. This review covers several issues related to cold-active β-galactosidases, including their classification, structure and molecular mechanisms of cold adaptation. Moreover, their applications are discussed, focusing on the production of lactose-free dairy products as well as on the valorization of cheese whey and the synthesis of glycosyl building blocks for the food, cosmetic and pharmaceutical industries.
Identifiants
pubmed: 33477853
pii: md19010043
doi: 10.3390/md19010043
pmc: PMC7832830
pii:
doi:
Substances chimiques
Oligosaccharides
0
beta-Galactosidase
EC 3.2.1.23
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
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