Quantification of serum C-mannosyl tryptophan by novel assay to evaluate renal function and vascular complications in patients with type 2 diabetes.
Journal
Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288
Informations de publication
Date de publication:
21 01 2021
21 01 2021
Historique:
received:
13
05
2020
accepted:
06
01
2021
entrez:
22
1
2021
pubmed:
23
1
2021
medline:
7
10
2021
Statut:
epublish
Résumé
C-Mannosyl tryptophan (CMW) is a unique glycosylated amino acid, and a candidate novel biomarker of renal function. In type 2 diabetes (T2D), a combination of metabolites including CMW has recently been the focus of novel biomarkers for the evaluation of renal function and prediction of its decline. However, previous quantification methods for serum CMW have several limitations. We recently established a novel assay for quantifying serum CMW. Serum CMW from 99 Japanese patients with T2D was quantified by this assay using hydrophilic interaction liquid chromatography. The serum CMW levels were cross-sectionally characterized in relation to clinical features, including renal function and vascular complications. Serum CMW level was more strongly correlated with serum creatinine and cystatin C levels and with eGFR than with albumin urea level. The ROC curve to detect eGFR < 60 ml/min/1.73 m
Identifiants
pubmed: 33479412
doi: 10.1038/s41598-021-81479-y
pii: 10.1038/s41598-021-81479-y
pmc: PMC7820242
doi:
Substances chimiques
Biomarkers
0
Cystatin C
0
Tryptophan
8DUH1N11BX
Creatine
MU72812GK0
Mannose
PHA4727WTP
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1946Subventions
Organisme : Japan Society for the Promotion of Science
ID : JP18K16242
Organisme : Japan Society for the Promotion of Science
ID : JP16H06290
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