Influenza- and MCMV-induced memory CD8 T cells control respiratory vaccinia virus infection despite residence in distinct anatomical niches.
Animals
CD8-Positive T-Lymphocytes
/ immunology
Cell Proliferation
Cells, Cultured
Herpesviridae Infections
/ immunology
Humans
Immunologic Memory
Influenza A virus
/ physiology
Influenza, Human
/ immunology
Lung
/ immunology
Lymphocyte Activation
Mice
Mice, Inbred C57BL
Mice, Transgenic
Muromegalovirus
/ physiology
Orthomyxoviridae Infections
/ immunology
Vaccinia
/ immunology
Vaccinia virus
/ physiology
Virus Activation
Virus Latency
Journal
Mucosal immunology
ISSN: 1935-3456
Titre abrégé: Mucosal Immunol
Pays: United States
ID NLM: 101299742
Informations de publication
Date de publication:
05 2021
05 2021
Historique:
received:
24
07
2020
accepted:
14
12
2020
revised:
25
11
2020
pubmed:
23
1
2021
medline:
21
12
2021
entrez:
22
1
2021
Statut:
ppublish
Résumé
Induction of memory CD8 T cells residing in peripheral tissues is of interest for T cell-based vaccines as these cells are located at mucosal and barrier sites and can immediately exert effector functions, thus providing protection in case of local pathogen encounter. Different memory CD8 T cell subsets patrol peripheral tissues, but it is unclear which subset is superior in providing protection upon secondary infections. We used influenza virus to induce predominantly tissue resident memory T cells or cytomegalovirus to elicit a large pool of effector-like memory cells in the lungs and determined their early protective capacity and mechanism of reactivation. Both memory CD8 T cell pools have unique characteristics with respect to their phenotype, localization, and maintenance. However, these distinct features do not translate into different capacities to control a respiratory vaccinia virus challenge in an antigen-specific manner, although differential activation mechanisms are utilized. While influenza-induced memory CD8 T cells respond to antigen by local proliferation, MCMV-induced memory CD8 T cells relocate from the vasculature into the tissue in an antigen-independent and partially chemokine-driven manner. Together these results bear relevance for the development of vaccines aimed at eliciting a protective memory CD8 T cell pool at mucosal sites.
Identifiants
pubmed: 33479479
doi: 10.1038/s41385-020-00373-4
pii: S1933-0219(22)00172-6
pmc: PMC8075924
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
728-742Subventions
Organisme : Medical Research Council
ID : MC_UU12018/7
Pays : United Kingdom
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