Safety of research bronchoscopy with BAL in stable adult patients with cystic fibrosis.
Journal
PloS one
ISSN: 1932-6203
Titre abrégé: PLoS One
Pays: United States
ID NLM: 101285081
Informations de publication
Date de publication:
2021
2021
Historique:
received:
18
09
2020
accepted:
05
01
2021
entrez:
22
1
2021
pubmed:
23
1
2021
medline:
16
6
2021
Statut:
epublish
Résumé
Data on adverse events from research bronchoscopy with bronchoalveolar lavage (BAL) in patients with cystic fibrosis (CF) is lacking. As research bronchoscopy with BAL is useful for isolation of immune cells and investigation of CF lung microbiome, we sought to investigate the safety of bronchoscopy in adult patients with CF. Between November 2016 and September 2019, we performed research bronchoscopies on CF subjects (32) and control subjects (82). Control subjects were nonsmokers without respiratory disease. CF subjects had mild or moderate obstructive lung disease (FEV1 > 50% predicted) and no evidence of recent CF pulmonary exacerbation. There was no significant difference in the age or sex of each cohort. Neither group experienced life threatening adverse events. The number of adverse events was similar between CF and control subjects. The most common adverse events were sore throat and cough, which occurred at similar frequencies in control and CF subjects. Fever and headache occurred more frequently in CF subjects. However, the majority of fevers were seen in CF subjects with FEV1 values below 65% predicted. We found that CF subjects had similar adverse event profiles following research bronchoscopy compared to healthy subjects. While CF subjects had a higher rate of fevers, this adverse event occurred with greater frequency in CF subjects with lower FEV1. Our data demonstrate that research bronchoscopy with BAL is safe in CF subjects and that safety profile is improved if bronchoscopies are limited to subjects with an FEV1 > 65% predicted.
Identifiants
pubmed: 33481845
doi: 10.1371/journal.pone.0245696
pii: PONE-D-20-29504
pmc: PMC7822334
doi:
Types de publication
Clinical Trial
Comparative Study
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
e0245696Subventions
Organisme : NHLBI NIH HHS
ID : K24 HL150453
Pays : United States
Organisme : NIDDK NIH HHS
ID : P30 DK117469
Pays : United States
Organisme : NIGMS NIH HHS
ID : P30 GM106394
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL122372
Pays : United States
Déclaration de conflit d'intérêts
The authors have declared that no competing interests exist.
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