An increase in CD62L
CD62L
COVID-19
Intensive Care Unit
L-selectin
Neutrophils
SARS-CoV-2
Thrombosis
pulmonary embolism
Journal
Scandinavian journal of immunology
ISSN: 1365-3083
Titre abrégé: Scand J Immunol
Pays: England
ID NLM: 0323767
Informations de publication
Date de publication:
Jun 2021
Jun 2021
Historique:
revised:
06
12
2020
received:
25
09
2020
accepted:
17
01
2021
pubmed:
23
1
2021
medline:
2
6
2021
entrez:
22
1
2021
Statut:
ppublish
Résumé
A high incidence of pulmonary embolism (PE) is reported in patients with critical coronavirus disease 2019 (COVID-19). Neutrophils may contribute to this through a process referred to as immunothrombosis. The aim of this study was to investigate the occurrence of neutrophil subpopulations in blood preceding the development of COVID-19 associated PE. We studied COVID-19 patients admitted to the ICU of our tertiary hospital between 19-03-2020 and 17-05-2020. Point-of-care fully automated flow cytometry was performed prior to ICU admission, measuring the neutrophil activation/maturation markers CD10, CD11b, CD16 and CD62L. Neutrophil receptor expression was compared between patients who did or did not develop PE (as diagnosed on CT angiography) during or after their ICU stay. Among 25 eligible ICU patients, 22 subjects were included for analysis, of whom nine developed PE. The median (IQR) time between neutrophil phenotyping and PE occurrence was 9 (7-12) days. A significant increase in the immune-suppressive neutrophil phenotype CD16 The increase in this neutrophil phenotype indicates that the increased number of CD16
Identifiants
pubmed: 33482019
doi: 10.1111/sji.13023
pmc: PMC7995011
doi:
Substances chimiques
Biomarkers
0
SELL protein, human
0
L-Selectin
126880-86-2
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
e13023Subventions
Organisme : Netherlands Organisation for Scientific Research
ID : Startimpuls Dutch research Agenda
Investigateurs
Feike Stiphout
(F)
Thomas M P Nijdam
(TMP)
Nils L M van de Ven
(NLM)
Remi Verhaegh
(R)
Judith S Spanjaard
(JS)
Benjamin W Verboeket
(BW)
Duco Laane
(D)
Karlijn van Wessem
(K)
Daan E J van Spengler
(DEJ)
Wiebe Buitenwerf
(W)
Giulio Giustarini
(G)
Eva Mulder
(E)
Harry Heijerman
(H)
Amely Daza Zabaleta
(AD)
Frederique van den Bos
(F)
Emma Rademaker
(E)
Meri R J Varkila
(MRJ)
Nikki de Mul
(N)
Olaf L Cremer
(OL)
Arjen Slooter
(A)
Eveline M Delemarre
(EM)
Stefan Nierkens
(S)
Maarten Limper
(M)
Femke van Wijk
(F)
Aridaman Pandit
(A)
Helen Leavis
(H)
Chantal C Clark
(CC)
Arjan D Barendrecht
(AD)
Cor W Seinen
(CW)
Sandra Drost-Verhoef
(S)
Simone Smits
(S)
Naomi M J Parr
(NMJ)
Sylvie A E Sebastian
(SAE)
Arnold C Koekman
(AC)
Annet C van Wesel
(AC)
Erhard van der Vries
(E)
Coen Maas
(C)
Steven de Maat
(S)
Saskia Haitjema
(S)
Imo E Hoefer
(IE)
Informations de copyright
© 2021 The Authors. Scandinavian Journal of Immunology published by John Wiley & Sons Ltd on behalf of The Scandinavian Foundation for Immunology.
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