A centric view of JAK/STAT5 in intestinal homeostasis, infection, and inflammation.
Infection
Inflammation
Intestinal epithelial stem cells
Intestinal homeostasis
STAT5A
STAT5B, JAK
Journal
Cytokine
ISSN: 1096-0023
Titre abrégé: Cytokine
Pays: England
ID NLM: 9005353
Informations de publication
Date de publication:
03 2021
03 2021
Historique:
received:
09
10
2020
revised:
25
11
2020
accepted:
26
11
2020
pubmed:
23
1
2021
medline:
13
1
2022
entrez:
22
1
2021
Statut:
ppublish
Résumé
Cytokines, growth factors or hormones take action through the JAK/STAT5 signaling pathway, which plays a critical role in regulating the intestinal response to infection and inflammation. However, the way in which STAT5 regulates intestinal epithelial compartment is largely ignored due to the lack of genetic tools for proper exploration and because the two STAT5 transcription factors (STAT5A and STAT5B) have some redundant but also distinct functions. In this review article, by focusing on STAT5 functions in the intestinal undifferentiated and differentiated epithelia, we discuss major advances of the growth factor/cytokine-JAK/STAT5 research in view of intestinal mucosal inflammation and immunity. We highlight the gap in the research of the intestinal STAT5 signaling to anticipate the gastrointestinal explorative insights. Furthermore, we address the critical questions to illuminate how STAT5 signaling influences intestinal epithelial cell differentiation and stem cell regeneration during homeostasis and injury. Overall, our article provides a centric view of the relevance of the relationship between chronic inflammatory diseases and JAK/STAT5 pathway and it also gives an example of how chronic infection and inflammation pirate STAT5 signaling to worsen intestinal injuries. Importantly, our review suggests how to protect a wound healing from gastrointestinal diseases by modulating intestinal STAT5.
Identifiants
pubmed: 33482575
pii: S1043-4666(20)30408-7
doi: 10.1016/j.cyto.2020.155392
pmc: PMC8276772
mid: NIHMS1713955
pii:
doi:
Substances chimiques
STAT5 Transcription Factor
0
Janus Kinases
EC 2.7.10.2
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
155392Subventions
Organisme : Austrian Science Fund FWF
ID : I 4157
Pays : Austria
Organisme : NIDDK NIH HHS
ID : P30 DK078392
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01 DK123299
Pays : United States
Informations de copyright
Copyright © 2020 The Authors. Published by Elsevier Ltd.. All rights reserved.
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