Gut Microbiota Condition the Therapeutic Efficacy of Trastuzumab in HER2-Positive Breast Cancer.
Animals
Anti-Bacterial Agents
/ pharmacology
Antineoplastic Agents, Immunological
/ therapeutic use
Breast Neoplasms
/ chemistry
Bridged-Ring Compounds
/ therapeutic use
CD4-Positive T-Lymphocytes
Cyclophosphamide
/ therapeutic use
Cytokines
/ blood
Dendritic Cells
/ drug effects
Doxorubicin
/ therapeutic use
Fecal Microbiota Transplantation
Female
Gastrointestinal Microbiome
/ drug effects
Granzymes
Humans
Immune System
Immunity, Mucosal
Interferons
/ metabolism
Interleukin-12
/ metabolism
Mice
Neoadjuvant Therapy
Nitric Oxide
/ metabolism
Receptor, ErbB-2
Streptomycin
/ pharmacology
Taxoids
/ therapeutic use
Trastuzumab
/ therapeutic use
Treatment Outcome
Tumor Microenvironment
/ drug effects
Vancomycin
/ pharmacology
Journal
Cancer research
ISSN: 1538-7445
Titre abrégé: Cancer Res
Pays: United States
ID NLM: 2984705R
Informations de publication
Date de publication:
15 04 2021
15 04 2021
Historique:
received:
18
05
2020
revised:
17
11
2020
accepted:
28
12
2020
pubmed:
24
1
2021
medline:
14
9
2021
entrez:
23
1
2021
Statut:
ppublish
Résumé
Emerging evidence indicates that gut microbiota affect the response to anticancer therapies by modulating the host immune system. In this study, we investigated the impact of gut microbiota on immune-mediated trastuzumab antitumor efficacy in preclinical models of HER2-positive breast cancer and in 24 patients with primary HER2-positive breast cancer undergoing trastuzumab-containing neoadjuvant treatment. In mice, the antitumor activity of trastuzumab was impaired by antibiotic administration or fecal microbiota transplantation from antibiotic-treated donors. Modulation of the intestinal microbiota was reflected in tumors by impaired recruitment of CD4
Identifiants
pubmed: 33483370
pii: 0008-5472.CAN-20-1659
doi: 10.1158/0008-5472.CAN-20-1659
doi:
Substances chimiques
Anti-Bacterial Agents
0
Antineoplastic Agents, Immunological
0
Bridged-Ring Compounds
0
Cytokines
0
Taxoids
0
taxane
1605-68-1
Interleukin-12
187348-17-0
Nitric Oxide
31C4KY9ESH
Vancomycin
6Q205EH1VU
Doxorubicin
80168379AG
Cyclophosphamide
8N3DW7272P
Interferons
9008-11-1
Receptor, ErbB-2
EC 2.7.10.1
Granzymes
EC 3.4.21.-
Trastuzumab
P188ANX8CK
Streptomycin
Y45QSO73OB
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
2195-2206Commentaires et corrections
Type : CommentIn
Informations de copyright
©2021 American Association for Cancer Research.
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