Reciprocal organ interactions during heart failure: a position paper from the ESC Working Group on Myocardial Function.
Liver
Adipose tissue
Brain
Heart failure
Intestine
Kidney
Lung
Multi-organ clinical syndrome
Non-coding RNAs
Journal
Cardiovascular research
ISSN: 1755-3245
Titre abrégé: Cardiovasc Res
Pays: England
ID NLM: 0077427
Informations de publication
Date de publication:
01 11 2021
01 11 2021
Historique:
received:
10
09
2020
revised:
20
11
2021
accepted:
08
01
2021
pubmed:
24
1
2021
medline:
2
2
2022
entrez:
23
1
2021
Statut:
ppublish
Résumé
Heart failure-either with reduced or preserved ejection fraction (HFrEF/HFpEF)-is a clinical syndrome of multifactorial and gender-dependent aetiology, indicating the insufficiency of the heart to pump blood adequately to maintain blood flow to meet the body's needs. Typical symptoms commonly include shortness of breath, excessive fatigue with impaired exercise capacity, and peripheral oedema, thereby alluding to the fact that heart failure is a syndrome that affects multiple organ systems. Patients suffering from progressed heart failure have a very limited life expectancy, lower than that of numerous cancer types. In this position paper, we provide an overview regarding interactions between the heart and other organ systems, the clinical evidence, underlying mechanisms, potential available or yet-to-establish animal models to study such interactions and finally discuss potential new drug interventions to be developed in the future. Our working group suggests that more experimental research is required to understand the individual molecular mechanisms underlying heart failure and reinforces the urgency for tailored therapeutic interventions that target not only the heart but also other related affected organ systems to effectively treat heart failure as a clinical syndrome that affects and involves multiple organs.
Identifiants
pubmed: 33483724
pii: 6105178
doi: 10.1093/cvr/cvab009
pmc: PMC8562335
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
2416-2433Subventions
Organisme : British Heart Foundation
Pays : United Kingdom
Organisme : BHF Project
ID : PG/17/64/33205
Organisme : European Union Commission's Seventh Framework program
ID : GA 305507
Organisme : EU Horizon 2020 project CARDIOREGENIX (GA
ID : 825670
Organisme : ERA-Net-CVD project MacroERA
ID : 01KL1706
Organisme : IMI2-CARDIATEAM
ID : 821508
Organisme : Netherlands Cardiovascular Research Initiative-an initiative with support of the Dutch Heart Foundation
ID : CVON2016-Early HFPEF, 2015-10
Organisme : CVON She-PREDICTS
Organisme : CVON Arena-PRIME, 2017-18
Organisme : CVON 2018-28 & 2012-06 Heart Brain Connection
Organisme : CVON-Dosis 2014-20
Organisme : Research Foundation Flanders FWO
ID : G091018N
Organisme : Deutsche Forschungsgemeinschaft
ID : KFO311/TH903/20
Organisme : AIRC
ID : IG 2016 19032
Organisme : Dutch Federation of University Medical Centres
Organisme : Netherlands Organisation for Health Research and Development and the Royal Netherlands Academy of Sciences
Organisme : Netherlands Organization for Sciences-ZonMW (VICI
ID : 91818602
Organisme : Project NETDIAMOND
ID : POCI-01-0145-FEDER-016385
Organisme : European Structural and Investment Funds
Organisme : Lisbon's Regional Operational Program 2020
Organisme : Portuguese Foundation for Science and Technology
Informations de copyright
© The Author(s) 2021. Published by Oxford University Press on behalf of the European Society of Cardiology.
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