Proteinuria in COVID-19: prevalence, characterization and prognostic role.
COVID-19
Proteinuria
Tubular proteinuria
α1-microglobulin
Journal
Journal of nephrology
ISSN: 1724-6059
Titre abrégé: J Nephrol
Pays: Italy
ID NLM: 9012268
Informations de publication
Date de publication:
04 2021
04 2021
Historique:
received:
25
07
2020
accepted:
18
11
2020
pubmed:
24
1
2021
medline:
22
4
2021
entrez:
23
1
2021
Statut:
ppublish
Résumé
Proteinuria has been commonly reported in patients with COVID-19. However, only dipstick tests have been frequently used thus far. Here, the quantification and characterization of proteinuria were investigated and their association with mortality was assessed. This retrospective, observational, single center study included 153 patients, hospitalized with COVID-19 between March 28th and April 30th, 2020, in whom total proteinuria and urinary α According to the Kidney Disease Improving Global Outcomes staging, 14% (n = 21) of the patients had category 1 proteinuria (< 150 mg/g of urine creatinine), 42% (n = 64) had category 2 (between 150 and 500 mg/g) and 44% (n = 68) had category 3 proteinuria (over 500 mg/g). Urine α Proteinuria is frequent in patients with COVID-19. Its characterization suggests a tubular origin, with increased urinary α
Sections du résumé
BACKGROUND
Proteinuria has been commonly reported in patients with COVID-19. However, only dipstick tests have been frequently used thus far. Here, the quantification and characterization of proteinuria were investigated and their association with mortality was assessed.
METHODS
This retrospective, observational, single center study included 153 patients, hospitalized with COVID-19 between March 28th and April 30th, 2020, in whom total proteinuria and urinary α
RESULTS
According to the Kidney Disease Improving Global Outcomes staging, 14% (n = 21) of the patients had category 1 proteinuria (< 150 mg/g of urine creatinine), 42% (n = 64) had category 2 (between 150 and 500 mg/g) and 44% (n = 68) had category 3 proteinuria (over 500 mg/g). Urine α
CONCLUSIONS
Proteinuria is frequent in patients with COVID-19. Its characterization suggests a tubular origin, with increased urinary α
Identifiants
pubmed: 33484426
doi: 10.1007/s40620-020-00931-w
pii: 10.1007/s40620-020-00931-w
pmc: PMC7823174
doi:
Substances chimiques
Biomarkers
0
Types de publication
Journal Article
Observational Study
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
355-364Commentaires et corrections
Type : CommentIn
Références
Clin Chem Lab Med. 2014 Apr;52(4):537-46
pubmed: 24243749
J Am Soc Nephrol. 2020 Aug;31(8):1683-1687
pubmed: 32371536
N Engl J Med. 2020 Feb 20;382(8):727-733
pubmed: 31978945
J Am Soc Nephrol. 2019 Oct;30(10):1785-1805
pubmed: 31506289
Nephron. 2020;144(5):213-221
pubmed: 32203970
N Engl J Med. 2020 Jun 11;382(24):2372-2374
pubmed: 32302078
Kidney Int. 2020 May;97(5):829-838
pubmed: 32247631
Lancet. 2020 May 16;395(10236):e87-e88
pubmed: 32423587
Nat Commun. 2021 May 4;12(1):2506
pubmed: 33947851
BMJ. 2020 May 22;369:m1985
pubmed: 32444460
J Clin Pathol. 1983 Mar;36(3):253-9
pubmed: 6186698
Kidney Int. 2020 Aug;98(2):505-506
pubmed: 32446936
Kidney Int. 2020 Jul;98(1):241
pubmed: 32471641
Lancet Infect Dis. 2020 Jun;20(6):656-657
pubmed: 32199493
J Am Soc Nephrol. 2020 Jun;31(6):1157-1165
pubmed: 32345702
Clin Biochem Rev. 2016 Feb;37(1):17-26
pubmed: 27057075
J Am Soc Nephrol. 2020 Jul;31(7):1380-1383
pubmed: 32366514
Kidney Int. 2020 Jul;98(1):219-227
pubmed: 32327202
J Nephrol. 2021 Apr;34(2):411-432
pubmed: 32328900
Eur Heart J. 2020 May 14;41(19):1821-1829
pubmed: 32383763
Lancet. 2020 Feb 15;395(10223):497-506
pubmed: 31986264
J Med Virol. 2020 Sep;92(9):1676-1680
pubmed: 32330305
Kidney Int. 2020 Jul;98(1):209-218
pubmed: 32416116
Clin Infect Dis. 2020 Nov 5;71(8):1962-1968
pubmed: 32472676
JAMA. 2020 May 12;323(18):1843-1844
pubmed: 32159775
Cell. 2020 Apr 16;181(2):271-280.e8
pubmed: 32142651