Variability of white matter anatomy in the subcallosal cingulate area.
Adult
Corpus Callosum
/ anatomy & histology
Depressive Disorder, Major
/ diagnostic imaging
Diffusion Tensor Imaging
/ methods
Gyrus Cinguli
/ anatomy & histology
Humans
Nerve Net
/ anatomy & histology
Prefrontal Cortex
/ anatomy & histology
Ventral Striatum
/ anatomy & histology
White Matter
/ anatomy & histology
anatomy
depression
probabilistic Tractography
subcallosal cingulate
Journal
Human brain mapping
ISSN: 1097-0193
Titre abrégé: Hum Brain Mapp
Pays: United States
ID NLM: 9419065
Informations de publication
Date de publication:
05 2021
05 2021
Historique:
revised:
16
12
2020
received:
16
07
2020
accepted:
28
12
2020
pubmed:
24
1
2021
medline:
1
2
2022
entrez:
23
1
2021
Statut:
ppublish
Résumé
The subcallosal cingulate (SCC) area is a putative hub in the brain network underlying depression. Deep brain stimulation (DBS) targeting a particular subregion of SCC, identified as the intersection of forceps minor (FM), uncinate fasciculus (UCF), cingulum and fronto-striatal fiber bundles, may be critical to a therapeutic response in patients with severe, treatment-resistant forms of major depressive disorder (MDD). The pattern and variability of the white matter anatomy and organization within SCC has not been extensively characterized across individuals. The goal of this study is to investigate the variability of white matter bundles within the SCC that structurally connect this region with critical nodes in the depression network. Structural and diffusion data from 100 healthy subjects from the Human Connectome Project database were analyzed. Anatomically defined SCC regions were used as seeds to perform probabilistic tractography and to estimate the connectivity from the SCC to subject-specific target areas believed to be involved in the pathology of MDD including ventral striatum (VS), UCF, anterior cingulate cortex (ACC), and medial prefrontal cortex (mPFC). Four distinct areas of connectivity were identified within SCC across subjects: (a) postero-lateral SCC connectivity to medial temporal regions via UCF, (b) postero-medial connectivity to VS, (c) superior-medial connectivity to ACC via cingulum bundle, and (d) antero-lateral connectivity to mPFC regions via forceps minor. Assuming white matter connectivity is critical to therapeutic response, the improved anatomic understanding of SCC as well as an appreciation of the intersubject variability are critical to developing optimized therapeutic targeting for SCC DBS.
Identifiants
pubmed: 33484503
doi: 10.1002/hbm.25341
pmc: PMC8046077
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
2005-2017Subventions
Organisme : NINDS NIH HHS
ID : UH3 NS103549
Pays : United States
Informations de copyright
© 2021 The Authors. Human Brain Mapping published by Wiley Periodicals LLC.
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