Predisposition to cancer in children and adolescents.

Adolescent Child Female Genetic Predisposition to Disease Genetic Testing Humans Male Medical Oncology / methods Neoplasms / genetics Risk Assessment

Journal

The Lancet. Child & adolescent health
ISSN: 2352-4650
Titre abrégé: Lancet Child Adolesc Health
Pays: England
ID NLM: 101712925

Informations de publication

Date de publication:
02 2021
Historique:
received: 17 06 2019
revised: 04 08 2020
accepted: 11 08 2020
entrez: 23 1 2021
pubmed: 24 1 2021
medline: 20 2 2021
Statut: ppublish

Résumé

Childhood malignancies are rarely related to known environmental exposures, and it has become increasingly evident that inherited genetic factors play a substantial causal role. Large-scale sequencing studies have shown that approximately 10% of children with cancer have an underlying cancer predisposition syndrome. The number of recognised cancer predisposition syndromes and cancer predisposition genes are constantly growing. Imaging and laboratory technologies are improving, and knowledge of the range of tumours and risk of malignancy associated with cancer predisposition syndromes is increasing over time. Consequently, surveillance measures need to be constantly adjusted to address these new findings. Management recommendations for individuals with pathogenic germline variants in cancer predisposition genes need to be established through international collaborative studies, addressing issues such as genetic counselling, cancer prevention, cancer surveillance, cancer therapy, psychological support, and social-ethical issues. This Review represents the work by a group of experts from the European Society for Paediatric Oncology (SIOPE) and aims to summarise the current knowledge and define future research needs in this evolving field.

Identifiants

DOI: 10.1016/S2352-4642(20)30275-3 PMID: 33484663
pubmed: 33484663
pii: S2352-4642(20)30275-3
doi: 10.1016/S2352-4642(20)30275-3
pii:
doi:

Types de publication

Journal Article Research Support, Non-U.S. Gov't Review

Langues

eng

Sous-ensembles de citation

IM

Pagination

142-154

Subventions

Organisme : Department of Health
Pays : United Kingdom

Informations de copyright

Copyright © 2021 Elsevier Ltd. All rights reserved.

Auteurs

Christian P Kratz (CP)

Paediatric Haematology and Oncology, Hannover Medical School, Hannover, Germany.

Marjolijn C Jongmans (MC)

Princess Máxima Center for Paediatric Oncology, Utrecht, Netherlands; Department of Genetics, University Medical Center Utrecht, Princess Máxima Center for Paediatric Oncology, Utrecht, Netherlands.

Hélène Cavé (H)

Department of Genetics, Assistance Publique Hôpitaux de Paris-Robert Debre University Hospital, Paris, France; Denis Diderot School of Medicine, University of Paris, Paris, France; Institut National de la Santé et de la Recherche Médicale (INSERM), UMR 1131, Institut de Recherche Saint Louis, Paris, France.

Katharina Wimmer (K)

Institute of Human Genetics, Medical University of Innsbruck, Innsbruck, Austria.

Sam Behjati (S)

Wellcome Sanger Institute, Cambridge, UK; Department of Paediatrics, University of Cambridge, Cambridge, UK.

Lea Guerrini-Rousseau (L)

Department of Children and Adolescents Oncology, Gustave Roussy, Villejuif, Paris, France.

Till Milde (T)

Clinical Cooperation Unit Paediatric Oncology, German Cancer Research Center and German Consortium for Translational Cancer Research, Heidelberg, Germany; KiTZ Clinical Trial Unit, Department of Paediatric Haematology and Oncology, Heidelberg University Hospital, Heidelberg, Germany; Hopp Children's Cancer Center Heidelberg (KiTZ), Heidelberg, Germany.

Kristian W Pajtler (KW)

Clinical Cooperation Unit Paediatric Oncology, German Cancer Research Center and German Consortium for Translational Cancer Research, Heidelberg, Germany; KiTZ Clinical Trial Unit, Department of Paediatric Haematology and Oncology, Heidelberg University Hospital, Heidelberg, Germany; Hopp Children's Cancer Center Heidelberg (KiTZ), Heidelberg, Germany.

Lisa Golmard (L)

Department of Genetics, Institut Curie, Paris, France; Paris Sciences Lettres Research University, Paris, France.

Marion Gauthier-Villars (M)

Department of Genetics, Institut Curie, Paris, France; Paris Sciences Lettres Research University, Paris, France.

Rosalyn Jewell (R)

Yorkshire Regional Genetics Service, Chapel Allerton Hospital, Leeds Teaching Hospitals NHS Trust, Leeds, UK.

Catriona Duncan (C)

Paediatric Oncology, London, UK.

Eamonn R Maher (ER)

Department of Medical Genetics, University of Cambridge, Cambridge, UK; NIHR Cambridge Biomedical Research Centre and Cancer Research UK Cambridge Centre, Cambridge Biomedical Campus, Cambridge, UK.

Laurence Brugieres (L)

Department of Children and Adolescents Oncology, Gustave Roussy, Villejuif, Paris, France.

Kathy Pritchard-Jones (K)

Great Ormond Street Hospital for Children NHS Foundation Trust, London, UK; UCL Great Ormond Street Institute of Child Health, University College London, London, UK.

Franck Bourdeaut (F)

SIREDO Paediatric Cancer Center, Institut Curie, Paris, France; INSERM U830, Laboratory of Translational Research in Paediatric Oncology, Institut Curie, Paris, France; Paris Sciences Lettres Research University, Paris, France. Electronic address: franck.bourdeaut@curie.fr.

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Classifications MeSH

questionsmedicales.fr › Personnes › Tranches d'âge › Adolescent › Predisposition to cancer in children and adolescents.
questionsmedicales.fr › Personnes › Tranches d'âge › Enfant › Predisposition to cancer in children and adolescents.
questionsmedicales.fr › Phénomènes génétiques › Génotype › Prédisposition génétique à une maladie › Predisposition to cancer in children and adolescents.
questionsmedicales.fr › Établissements, main d'oeuvre et services de soins de santé › Services de santé › Services de médecine préventive › Services de diagnostic › Dépistage génétique › Predisposition to cancer in children and adolescents.
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Predisposition to cancer in children and adolescents.
questionsmedicales.fr › Professions de santé › Médecine › Médecine interne › Oncologie médicale › Predisposition to cancer in children and adolescents.
questionsmedicales.fr › Tumeurs › Predisposition to cancer in children and adolescents.
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Statistiques comme sujet › Probabilité › Risque › Appréciation des risques › Predisposition to cancer in children and adolescents.