The Impact of Erythropoietin on Short- and Long-Term Kidney-Related Outcomes in Neonates of Extremely Low Gestational Age. Results of a Multicenter, Double-Blind, Placebo-Controlled Randomized Clinical Trial.
Acute Kidney Injury
/ classification
Albuminuria
/ epidemiology
Double-Blind Method
Erythropoietin
/ therapeutic use
Female
Gestational Age
Glomerular Filtration Rate
Humans
Hypertension
/ epidemiology
Infant, Extremely Premature
Infant, Newborn
Infant, Premature, Diseases
/ epidemiology
Male
Recombinant Proteins
/ therapeutic use
Renal Insufficiency, Chronic
/ epidemiology
acute kidney injury
acute renal failure
chronic kidney disease
hypertension
proteinuria
Journal
The Journal of pediatrics
ISSN: 1097-6833
Titre abrégé: J Pediatr
Pays: United States
ID NLM: 0375410
Informations de publication
Date de publication:
05 2021
05 2021
Historique:
received:
13
05
2020
revised:
10
12
2020
accepted:
14
01
2021
pubmed:
24
1
2021
medline:
31
8
2021
entrez:
23
1
2021
Statut:
ppublish
Résumé
To evaluate whether extremely low gestational age neonates (ELGANs) randomized to erythropoietin have better or worse kidney-related outcomes during hospitalization and at 22-26 months of corrected gestational age (cGA) compared with those randomized to placebo. We performed an ancillary study to a multicenter double-blind, placebo-controlled randomized clinical trial of erythropoietin in ELGANs. The prevalence of severe (stage 2 or 3) acute kidney injury (AKI) was 18.2%. We did not find a statistically significant difference between those randomized to erythropoietin vs placebo for in-hospital primary (severe AKI) or secondary outcomes (any AKI and serum creatinine/cystatin C values at days 0, 7, 9, and 14). At 22-26 months of cGA, 16% of the cohort had an estimated glomerular filtration rate (eGFR) <90 mL/min/1.73 m ELGANs have high rates of in-hospital AKI and kidney-related problems at 22-26 months of cGA. Recombinant erythropoietin may protect ELGANs against long-term elevated SBP but does not appear to protect from AKI, low eGFR, albuminuria, or elevated DBP at 22-26 months of cGA.
Identifiants
pubmed: 33484699
pii: S0022-3476(21)00065-2
doi: 10.1016/j.jpeds.2021.01.031
pmc: PMC8093092
mid: NIHMS1665021
pii:
doi:
Substances chimiques
Recombinant Proteins
0
Erythropoietin
11096-26-7
Types de publication
Journal Article
Multicenter Study
Randomized Controlled Trial
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
65-72.e7Subventions
Organisme : NIDDK NIH HHS
ID : P30 DK079337
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01 DK103608
Pays : United States
Organisme : NINDS NIH HHS
ID : U01 NS077953
Pays : United States
Organisme : NINDS NIH HHS
ID : U01 NS077955
Pays : United States
Investigateurs
Sandra E Juul
(SE)
Bryan A Comstock
(BA)
Rajan Wadhawan
(R)
Dennis E Mayock
(DE)
Sherry E Courtney
(SE)
Tonya Robinson
(T)
Kaashif A Ahmad
(KA)
Ellen Bendel-Stenzel
(E)
Mariana Baserga
(M)
Edmund F LaGamma
(EF)
L Corbin Downey
(LC)
Raghavendra Rao
(R)
Nancy Fahim
(N)
Andrea Lampland
(A)
Ivan D Frantz
(ID)
Janine Y Khan
(JY)
Michael Weiss
(M)
Maureen M Gilmore
(MM)
Robin Ohls
(R)
Nishant Srinivasan
(N)
Jorge E Perez
(JE)
Victor McKay
(V)
Phuong T Vu
(PT)
Patrick J Heagerty
(PJ)
Billy Thomas
(B)
Nahed Elhassan
(N)
Sarah Mulkey
(S)
Philip Dydynski
(P)
Vivek K Vijayamadhavan
(VK)
Neil Mulrooney
(N)
Bradley Yoder
(B)
Jordan S Kase
(JS)
Jennifer Check
(J)
Semsa Gogcu
(S)
Erin Osterholm
(E)
Sara Ramel
(S)
Catherine Bendel
(C)
Cheryl Gale
(C)
Thomas George
(T)
Michael Georgieff
(M)
Tate Gisslen
(T)
Sixto Guiang
(S)
Anne Hall
(A)
Dana Johnson
(D)
Katie Pfister
(K)
Heather Podgorski
(H)
Kari Roberts
(K)
Erin Stepka
(E)
Melissa Engel
(M)
Heidi Kamrath
(H)
Johannah Scheurer
(J)
Angela Hanson
(A)
Katherine Satrom
(K)
Susan Pfister
(S)
Ann Simones
(A)
Erin Plummer
(E)
Elizabeth Zorn
(E)
Camilia R Martin
(CR)
Deirdre O'Reilly
(D)
Nicolas Porta
(N)
Catalina Bazacliu
(C)
Jonathan Williams
(J)
Dhanashree Rajderkar
(D)
Frances Northington
(F)
Raul Chavez Valdez
(RC)
Sandra Beauman
(S)
Patel Saurabhkumar
(P)
Magaly Diaz-Barbosa
(M)
Arturo Serize
(A)
Jorge Jordan
(J)
Debbie Ott
(D)
Ariana Franco Mora
(AF)
Pamela Hedrick
(P)
Vicki Flynn
(V)
Amy Silvia
(A)
Bailey Clopp
(B)
John B Feltner
(JB)
Isabella Esposito
(I)
Stephanie Hauge
(S)
Samantha Nikirk
(S)
Andrea Purnell
(A)
Emilie Loy
(E)
Natalie Sikes
(N)
Melanie Mason
(M)
Jana McConnell
(J)
Tiffany Brown
(T)
Henry Harrison
(H)
Denise Pearson
(D)
Tammy Drake
(T)
Jocelyn Wright
(J)
Debra Walden
(D)
Annette Guy
(A)
Jennifer Nason
(J)
Morgan Talbot
(M)
Kristen Lee
(K)
Sarah Penny
(S)
Terri Boles
(T)
Melanie Drummond
(M)
Katy Kohlleppel
(K)
Charmaine Kathen
(C)
Brian Kaletka
(B)
Shania Gonzales
(S)
Cathy Worwa
(C)
Molly Fisher
(M)
Tyler Richter
(T)
Alexander Ginder
(A)
Brixen Reich
(B)
Carrie Rau
(C)
Manndi Loertscher
(M)
Laura Bledsoe
(L)
Kandace McGrath
(K)
Kimberlee Weaver Lewis
(KW)
Jill Burnett
(J)
Susan Schaefer
(S)
Karie Bird
(K)
Clare Giblin
(C)
Rita Daly
(R)
Kristi Lanier
(K)
Kelly Warden
(K)
Jenna Wassenaar
(J)
Jensina Ericksen
(J)
Bridget Davern
(B)
Mary Pat Osborne
(MP)
Brittany Gregorich
(B)
Neha Talele
(N)
Evelyn Obregon
(E)
Tiglath Ziyeh
(T)
Molly Clarke
(M)
Rachel E Wegner
(RE)
Palak Patel
(P)
Molly Schau
(M)
Annamarie Russow
(A)
Kelly Curry
(K)
Susan Sinnamon
(S)
Lisa Barnhart
(L)
Charlamaine Parkinson
(C)
Sandra Beauman
(S)
Mary Hanson
(M)
Elizabeth Kuan
(E)
Conra Backstrom Lacy
(CB)
Edshelee M Galvis
(EM)
Susana Bombino
(S)
Denise Martinez
(D)
Suzi Bell
(S)
Corrie Long
(C)
Cathy Longa
(C)
Michael Westerveld
(M)
Stacy McConkey
(S)
Anne Hay
(A)
Niranjana Natarajan
(N)
Shari Gaudette
(S)
Sarah Cobb
(S)
Gregory Sharp
(G)
Elizabeth Schumacher
(E)
Leslie Schuschke
(L)
Charlotte Frey
(C)
Mario Fierro
(M)
Lois Gilmore
(L)
Pamela Lundequam
(P)
Ronald Hoekstra
(R)
Anastasia Ketko
(A)
Nina Perdue
(N)
Sean Cunningham
(S)
Kelly Stout
(K)
Becky Hall
(B)
Galina Morshedzadeh
(G)
Betsy Ostrander
(B)
Sarah Winter
(S)
Lauren Cox
(L)
Jordan S Kase
(JS)
Matthew A Rainaldi
(MA)
Sarah Hensley
(S)
Melissa Morris
(M)
Dia Roberts
(D)
Semsa Gogcu
(S)
Melissa Tuttle
(M)
Christopher Boys
(C)
Solveig Hultgren
(S)
Elizabeth I Pierpont
(EI)
Nancy Fahim
(N)
Tom George
(T)
Erin Osterholm
(E)
Michael Georgieff
(M)
Kelly E King
(KE)
Katherine Bataglia
(K)
Cathy Neis
(C)
Mark Bergeron
(M)
Cristina Miller
(C)
Cara Accomando
(C)
Jennifer Anne Gavin
(JA)
Elizabeth Maczek
(E)
Susan Marakovitz
(S)
Aimee Knorr
(A)
Vincent C Smith
(VC)
Jane E Stewart
(JE)
Marie Weissbourd
(M)
Raye-Ann deRegnier
(RA)
Nana Matoba
(N)
Shelly C Heaton
(SC)
Erika M Cascio
(EM)
Janet Brady
(J)
Suman Ghosh
(S)
Jessica Ditto
(J)
Mary Leppert
(M)
Jean Lowe
(J)
Janell Fuller
(J)
Tara DuPont
(T)
Robin Ohls
(R)
Pamela Kloska
(P)
Saurabh Patel
(S)
Lauren Carbonell
(L)
Anna Maria Patino-Fernandez
(AM)
Carmen de Lerma
(C)
Susana Bombino
(S)
Arturo Serize
(A)
Kelly McDonough
(K)
Maiana De Cortada
(M)
Lacy Chavis
(L)
Jane Shannon
(J)
Bryan A Comstock
(BA)
Patrick J Heagerty
(PJ)
Mark A Konodi
(MA)
Christopher Nefcy
(C)
Phuong T Vu
(PT)
Karl C K Kuban
(KCK)
Jean R Lowe
(JR)
T Michael O'Shea
(TM)
Manjiri Dighe
(M)
Todd Richards
(T)
Dennis W W Shaw
(DWW)
Colin Studholme
(C)
Christopher M Traudt
(CM)
Roberta Ballard
(R)
Bryan A Comstock
(BA)
Adam Hartman
(A)
Scott Janis
(S)
Sandra E Juul
(SE)
Dennis E Mayock
(DE)
T Robin Ohls
(TR)
Michael O'Shea
(M)
Ronnie Guillet
(R)
M Bethany Ball
(MB)
Hannah Glass
(H)
Ben Saville
(B)
Michael Schreiber
(M)
Informations de copyright
Copyright © 2021 Elsevier Inc. All rights reserved.
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