Thrombotic antiphospholipid syndrome: A practical guide to diagnosis and management.
Anticoagulant-refractory
Clinical practice points
Direct oral anticoagulants
Recurrent thrombosis
Thrombotic antiphospholipid syndrome
Vitamin K antagonists
Journal
Thrombosis research
ISSN: 1879-2472
Titre abrégé: Thromb Res
Pays: United States
ID NLM: 0326377
Informations de publication
Date de publication:
02 2021
02 2021
Historique:
received:
05
08
2020
revised:
12
09
2020
accepted:
07
10
2020
pubmed:
24
1
2021
medline:
22
6
2021
entrez:
23
1
2021
Statut:
ppublish
Résumé
Thrombotic antiphospholipid syndrome (APS) is characterised by venous, arterial and/or small vessel thrombosis in the context of persistently positive antiphospholipid antibodies (aPL). The diagnosis and management of thrombotic APS continues to prove challenging for clinicians. We provide a practical guide to the diagnosis of APS including who to test for aPL and which tests to do. We also consider clinical practice points on the management of venous, arterial and small vessel thrombosis, in the context of first and recurrent thrombotic events. Non-criteria manifestations of APS are reviewed. An approach to recurrent thrombosis and anticoagulant-refractory APS is discussed, with options including increasing the anticoagulation intensity of vitamin K antagonists, switching to low-molecular-weight-heparin, the use of fondaparinux and/or the addition of antiplatelet treatment. Adjunctive options such as vitamin D, hydroxychloroquine and statins are also addressed.
Identifiants
pubmed: 33485122
pii: S0049-3848(20)30554-5
doi: 10.1016/j.thromres.2020.10.010
pmc: PMC7560059
pii:
doi:
Substances chimiques
Antibodies, Antiphospholipid
0
Anticoagulants
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
213-221Informations de copyright
Copyright © 2020 Elsevier Ltd. All rights reserved.
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