Engineering of Humanized Antibodies Against Human Interleukin 5 Receptor Alpha Subunit That Cause Potent Antibody-Dependent Cell-Mediated Cytotoxicity.
Animals
Anti-Asthmatic Agents
/ adverse effects
Antibodies, Monoclonal, Humanized
/ adverse effects
Antibody-Dependent Cell Cytotoxicity
/ immunology
Asthma
/ complications
Case-Control Studies
Eosinophils
/ drug effects
Epitope Mapping
/ methods
Epitopes
/ immunology
Humans
Immunization
Interleukin-5 Receptor alpha Subunit
/ antagonists & inhibitors
Killer Cells, Natural
/ immunology
Mice
Recombinant Proteins
IL-5
IL-5 receptor
antagonistic antibody
antibody engineering
antibody-dependent cell-mediated cytotoxicity
eosinophil
severe asthma
Journal
Frontiers in immunology
ISSN: 1664-3224
Titre abrégé: Front Immunol
Pays: Switzerland
ID NLM: 101560960
Informations de publication
Date de publication:
2020
2020
Historique:
received:
11
08
2020
accepted:
30
11
2020
entrez:
25
1
2021
pubmed:
26
1
2021
medline:
22
6
2021
Statut:
epublish
Résumé
Patients with severe eosinophilic asthma (SEA; characterized by persistent eosinophilia in blood and airway tissues) experience frequent asthma exacerbations with poor clinical outcomes. Interleukin 5 (IL-5) and IL-5 receptor alpha subunit (IL-5α) play key roles in eosinophilia maintenance, and relevant therapeutic strategies include the development of antibodies (Abs) against IL-5 or IL-5α to control eosinophilia. Benralizumab, an anti-IL-5α Ab that depletes eosinophils mainly
Identifiants
pubmed: 33488590
doi: 10.3389/fimmu.2020.593748
pmc: PMC7820887
doi:
Substances chimiques
Anti-Asthmatic Agents
0
Antibodies, Monoclonal, Humanized
0
Epitopes
0
IL5RA protein, human
0
Interleukin-5 Receptor alpha Subunit
0
Recombinant Proteins
0
benralizumab
71492GE1FX
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
593748Informations de copyright
Copyright © 2021 Kim, Lee, Jung, Kim, Choi, Park and Kim.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
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