Pharmacological evaluation of prophylactic anti-microbial use in laparoscopic cholecystectomy; an open labelled study evaluating the concentrations of single dose intravenous ceftriaxone at serum and tissue level.
Administration, Intravenous
Adolescent
Adult
Aged
Anti-Bacterial Agents
/ administration & dosage
Antibiotic Prophylaxis
/ methods
Ceftriaxone
/ administration & dosage
Cholecystectomy, Laparoscopic
/ methods
Drug Administration Schedule
Female
Humans
India
/ epidemiology
Male
Middle Aged
Prospective Studies
Risk Factors
Surgical Wound Infection
/ epidemiology
Tertiary Care Centers
Young Adult
Ceftriaxone
Laparoscopic cholecystectomy
Prophylaxis
Journal
European journal of clinical pharmacology
ISSN: 1432-1041
Titre abrégé: Eur J Clin Pharmacol
Pays: Germany
ID NLM: 1256165
Informations de publication
Date de publication:
Jul 2021
Jul 2021
Historique:
received:
02
01
2021
accepted:
14
01
2021
pubmed:
26
1
2021
medline:
20
11
2021
entrez:
25
1
2021
Statut:
ppublish
Résumé
The goal of administering preoperative systemic prophylactic antibiotics is to have the concentration in the tissues at its optimum level at the start and throughout the surgery. The rationale for the use of antibiotics is not well accepted; possible side effects and development of microbial resistance patterns are potential risks along with the financial burden. Therefore, the present study was conducted with the aim to clinically evaluate the serum and tissue concentration of single-dose prophylactic ceftriaxone during an ongoing laparoscopic cholecystectomy (LC) and to find out risk factors for post operative surgical site infections (SSI). It was an open labelled prospective study in 50 consecutive patients who underwent elective laparoscopic cholecystectomy under prophylactic cover of ceftriaxone. Serum and tissue concentration were estimated by High Performance Liquid Chromatography during the ongoing surgery. Subjects were observed for any post-operative complications including SSI. Serum and tissue concentrations of ceftriaxone were significant at test value of 4 milligrams/Litre. Body mass index was significantly correlated with the tissue concentration of ceftriaxone at the time of incision. The rate of SSI was 2%. It significantly correlated with age more than 60 years, diabetes and infected bile. A single prophylactic intra-venous dose of 1 g ceftriaxone immediately prior to skin incision in LC is good enough for prevention of SSI in Indian patients.
Identifiants
pubmed: 33492485
doi: 10.1007/s00228-021-03093-1
pii: 10.1007/s00228-021-03093-1
doi:
Substances chimiques
Anti-Bacterial Agents
0
Ceftriaxone
75J73V1629
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
1011-1016Commentaires et corrections
Type : ErratumIn
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