Loss of furin cleavage site attenuates SARS-CoV-2 pathogenesis.

Amino Acid Sequence Animals Antibodies, Neutralizing / immunology COVID-19 / pathology Cell Line Chlorocebus aethiops Cricetinae Female Furin / metabolism Humans Lung Diseases / pathology Male Mice Mice, Transgenic Models, Molecular Mutant Proteins / chemistry Mutation Proteolysis SARS-CoV-2 / chemistry Serine Endopeptidases / metabolism Spike Glycoprotein, Coronavirus / chemistry Vero Cells Virus Replication / genetics

Journal

Nature
ISSN: 1476-4687
Titre abrégé: Nature
Pays: England
ID NLM: 0410462

Informations de publication

Date de publication:
03 2021
Historique:
received: 26 08 2020
accepted: 13 01 2021
pubmed: 26 1 2021
medline: 18 3 2021
entrez: 25 1 2021
Statut: ppublish

Résumé

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-a new coronavirus that has led to a worldwide pandemic

Identifiants

DOI: 10.1038/s41586-021-03237-4 PMID: 33494095 PMC: PMC8175039
pubmed: 33494095
doi: 10.1038/s41586-021-03237-4
pii: 10.1038/s41586-021-03237-4
pmc: PMC8175039
mid: NIHMS1690490
doi:

Substances chimiques

Antibodies, Neutralizing 0
Mutant Proteins 0
Spike Glycoprotein, Coronavirus 0
spike protein, SARS-CoV-2 0
Serine Endopeptidases EC 3.4.21.-
TMPRSS2 protein, human EC 3.4.21.-
Furin EC 3.4.21.75

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, Non-P.H.S.

Langues

eng

Sous-ensembles de citation

IM

Pagination

293-299

Subventions

Organisme : NIAID NIH HHS
ID : R21 AI145400
Pays : United States
Organisme : NIA NIH HHS
ID : R00 AG049092
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI153602
Pays : United States
Organisme : NIAID NIH HHS
ID : T32 AI007163
Pays : United States
Organisme : NIAID NIH HHS
ID : T32 AI007526
Pays : United States
Organisme : NIAID NIH HHS
ID : R24 AI120942
Pays : United States
Organisme : NIAID NIH HHS
ID : F30 AI152327
Pays : United States

Commentaires et corrections

Type : UpdateOf

Références

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Auteurs

Bryan A Johnson (BA)

Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, TX, USA.

Xuping Xie (X)

Department of Biochemistry and Molecular Biology, University of Texas Medical Branch, Galveston, TX, USA.
ORCID: 0000-0003-0918-016X

Adam L Bailey (AL)

Department of Pathology and Immunology, Washington University School of Medicine, St Louis, MO, USA.
ORCID: 0000-0002-6560-9680

Birte Kalveram (B)

Department of Pathology, University of Texas Medical Branch, Galveston, TX, USA.

Kumari G Lokugamage (KG)

Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, TX, USA.

Antonio Muruato (A)

Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, TX, USA.

Jing Zou (J)

Department of Biochemistry and Molecular Biology, University of Texas Medical Branch, Galveston, TX, USA.

Xianwen Zhang (X)

Department of Biochemistry and Molecular Biology, University of Texas Medical Branch, Galveston, TX, USA.

Terry Juelich (T)

Department of Pathology, University of Texas Medical Branch, Galveston, TX, USA.

Jennifer K Smith (JK)

Department of Pathology, University of Texas Medical Branch, Galveston, TX, USA.

Lihong Zhang (L)

Department of Pathology, University of Texas Medical Branch, Galveston, TX, USA.

Nathen Bopp (N)

Department of Pathology, University of Texas Medical Branch, Galveston, TX, USA.

Craig Schindewolf (C)

Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, TX, USA.
ORCID: 0000-0002-9804-2246

Michelle Vu (M)

Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, TX, USA.

Abigail Vanderheiden (A)

Department of Pediatrics, Emory University School of Medicine, Atlanta, GA, USA.
Emory Vaccine Center, Emory University School of Medicine, Atlanta, GA, USA.

Emma S Winkler (ES)

Department of Pathology and Immunology, Washington University School of Medicine, St Louis, MO, USA.
Department of Medicine, Washington University School of Medicine, St Louis, MO, USA.

Daniele Swetnam (D)

Department of Biochemistry and Molecular Biology, University of Texas Medical Branch, Galveston, TX, USA.
ORCID: 0000-0002-6694-5571

Jessica A Plante (JA)

Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, TX, USA.
ORCID: 0000-0002-4768-7458

Patricia Aguilar (P)

Department of Pathology, University of Texas Medical Branch, Galveston, TX, USA.

Kenneth S Plante (KS)

Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, TX, USA.
ORCID: 0000-0002-7485-3167

Vsevolod Popov (V)

Department of Pathology, University of Texas Medical Branch, Galveston, TX, USA.

Benhur Lee (B)

Icahn School of Medicine at Mount Sinai, New York, NY, USA.
ORCID: 0000-0003-0760-1709

Scott C Weaver (SC)

Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, TX, USA.
Institute for Human Infection and Immunity, University of Texas Medical Branch, Galveston, TX, USA.
ORCID: 0000-0001-8016-8556

Mehul S Suthar (MS)

Department of Pediatrics, Emory University School of Medicine, Atlanta, GA, USA.
Emory Vaccine Center, Emory University School of Medicine, Atlanta, GA, USA.
Yerkes National Primate Research Center, Atlanta, GA, USA.

Andrew L Routh (AL)

Department of Biochemistry and Molecular Biology, University of Texas Medical Branch, Galveston, TX, USA.
ORCID: 0000-0002-2874-5990

Ping Ren (P)

Department of Pathology, University of Texas Medical Branch, Galveston, TX, USA.
ORCID: 0000-0002-4022-6667

Zhiqiang Ku (Z)

Texas Therapeutics Institute, Brown Foundation Institute of Molecular Medicine, University of Texas Health Science Center at Houston, Houston, USA.

Zhiqiang An (Z)

Texas Therapeutics Institute, Brown Foundation Institute of Molecular Medicine, University of Texas Health Science Center at Houston, Houston, USA.
ORCID: 0000-0001-9309-2335

Kari Debbink (K)

Department of Natural Sciences Bowie State University, Bowie, MD, USA.

Michael S Diamond (MS)

Department of Pathology and Immunology, Washington University School of Medicine, St Louis, MO, USA.
Department of Medicine, Washington University School of Medicine, St Louis, MO, USA.
Department of Molecular Microbiology, Washington University School of Medicine, St Louis, MO, USA.

Pei-Yong Shi (PY)

Department of Biochemistry and Molecular Biology, University of Texas Medical Branch, Galveston, TX, USA.
Institute for Human Infection and Immunity, University of Texas Medical Branch, Galveston, TX, USA.
ORCID: 0000-0001-5553-1616

Alexander N Freiberg (AN)

Department of Pathology, University of Texas Medical Branch, Galveston, TX, USA.
Institute for Human Infection and Immunity, University of Texas Medical Branch, Galveston, TX, USA.

Vineet D Menachery (VD)

Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, TX, USA. vimenach@utmb.edu.
Institute for Human Infection and Immunity, University of Texas Medical Branch, Galveston, TX, USA. vimenach@utmb.edu.
ORCID: 0000-0001-8803-7606

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Classifications MeSH

questionsmedicales.fr › Sciences de l'information › Sources d'information › Services d'information › Documentation › Données de séquences moléculaires › Séquence d'acides aminés › Loss of furin cleavage site attenuates...
questionsmedicales.fr › Eucaryotes › Animaux › Loss of furin cleavage site attenuates...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Globulines › Sérum-globulines › Immunoglobulines › Anticorps › Anticorps neutralisants › Loss of furin cleavage site attenuates...
questionsmedicales.fr › Maladies de l'appareil respiratoire › Infections de l'appareil respiratoire › Pneumopathie infectieuse › Pneumopathie virale › COVID-19 › Loss of furin cleavage site attenuates...
questionsmedicales.fr › Cellules › Cellules cultivées › Lignée cellulaire › Loss of furin cleavage site attenuates...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Cercopithecidae › Cercopithecinae › Cercopithecus › Cercopithecus aethiops › Loss of furin cleavage site attenuates...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Arvicolinae › Cricetinae › Loss of furin cleavage site attenuates...
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Hydrolases › Peptide hydrolases › Protéases à sérine › Serine endopeptidases › Furine › Loss of furin cleavage site attenuates...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Loss of furin cleavage site attenuates...
questionsmedicales.fr › Maladies de l'appareil respiratoire › Maladies pulmonaires › Loss of furin cleavage site attenuates...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Loss of furin cleavage site attenuates...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Souris transgéniques › Loss of furin cleavage site attenuates...
questionsmedicales.fr › Techniques d'investigation › Modèles théoriques › Modèles moléculaires › Loss of furin cleavage site attenuates...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines mutantes › Loss of furin cleavage site attenuates...
questionsmedicales.fr › Phénomènes génétiques › Variation génétique › Mutation › Loss of furin cleavage site attenuates...
questionsmedicales.fr › Métabolisme › Protéolyse › Loss of furin cleavage site attenuates...
questionsmedicales.fr › Virus › Virus à ARN › Virus à ARN à brin positif › Nidovirales › Coronaviridae › Coronavirus › Betacoronavirus › Virus du SRAS › SARS-CoV-2 › Loss of furin cleavage site attenuates...
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Hydrolases › Peptide hydrolases › Protéases à sérine › Serine endopeptidases › Loss of furin cleavage site attenuates...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines virales › Protéines virales structurales › Protéines de l'enveloppe virale › Protéines de fusion virale › Glycoprotéine de spicule des coronavirus › Loss of furin cleavage site attenuates...
questionsmedicales.fr › Cellules › Cellules épithéliales › Cellules Vero › Loss of furin cleavage site attenuates...
questionsmedicales.fr › Phénomènes microbiologiques › Phénomènes physiologiques viraux › Réplication virale › Loss of furin cleavage site attenuates...