Genome-wide study of a Neolithic Wartberg grave community reveals distinct HLA variation and hunter-gatherer ancestry.
Agriculture
Animals
Archaeology
DNA, Ancient
/ analysis
Europe
Evolution, Molecular
Feeding Behavior
/ physiology
Genetic Variation
Genetics, Population
Genome, Human
Genome-Wide Association Study
Germany
HLA Antigens
/ genetics
History, Ancient
Human Migration
Humans
Polymorphism, Single Nucleotide
Predatory Behavior
/ physiology
Racial Groups
/ genetics
Residence Characteristics
Journal
Communications biology
ISSN: 2399-3642
Titre abrégé: Commun Biol
Pays: England
ID NLM: 101719179
Informations de publication
Date de publication:
25 01 2021
25 01 2021
Historique:
received:
28
04
2020
accepted:
20
12
2020
entrez:
26
1
2021
pubmed:
27
1
2021
medline:
20
8
2021
Statut:
epublish
Résumé
The Wartberg culture (WBC, 3500-2800 BCE) dates to the Late Neolithic period, a time of important demographic and cultural transformations in western Europe. We performed genome-wide analyses of 42 individuals who were interred in a WBC collective burial in Niedertiefenbach, Germany (3300-3200 cal. BCE). The results showed that the farming population of Niedertiefenbach carried a surprisingly large hunter-gatherer ancestry component (34-58%). This component was most likely introduced during the cultural transformation that led to the WBC. In addition, the Niedertiefenbach individuals exhibited a distinct human leukocyte antigen gene pool, possibly reflecting an immune response that was geared towards detecting viral infections.
Identifiants
pubmed: 33495542
doi: 10.1038/s42003-020-01627-4
pii: 10.1038/s42003-020-01627-4
pmc: PMC7835224
doi:
Substances chimiques
DNA, Ancient
0
HLA Antigens
0
Types de publication
Historical Article
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
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