A specific neural substrate predicting current and future impulsivity in young adults.


Journal

Molecular psychiatry
ISSN: 1476-5578
Titre abrégé: Mol Psychiatry
Pays: England
ID NLM: 9607835

Informations de publication

Date de publication:
09 2021
Historique:
received: 12 06 2020
accepted: 05 01 2021
revised: 16 12 2020
pubmed: 27 1 2021
medline: 1 2 2022
entrez: 26 1 2021
Statut: ppublish

Résumé

Impulsivity (rash action with deleterious outcomes) is common to many psychiatric disorders. While some studies indicate altered amygdala and prefrontal cortical (PFC) activity associated with impulsivity, it remains unclear whether these patterns of neural activity are specific to impulsivity or common to a range of affective and anxiety symptoms. To elucidate neural markers specific to impulsivity, we aimed to differentiate patterns of amygdala-PFC activity and functional connectivity associated with impulsivity from those associated with affective and anxiety symptoms, and identify measures of this circuitry predicting future worsening of impulsivity. Using a face emotion processing task that reliably activates amygdala-PFC circuitry, neural activity and connectivity were assessed in a transdiagnostically-recruited sample of young adults, including healthy (N = 47) and treatment-seeking individuals (N = 67). Relationships were examined between neural measures and impulsivity, anhedonia, and affective and anxiety symptoms at baseline (N = 114), and at 6 months post scan (N = 30). Impulsivity, particularly negative urgency and lack of perseverance, was related to greater amygdala activity (beta = 0.82, p = 0.003; beta = 0.68, p = 0.004; respectively) and lower amygdala-medial PFC functional connectivity (voxels = 60, t

Identifiants

pubmed: 33495543
doi: 10.1038/s41380-021-01017-0
pii: 10.1038/s41380-021-01017-0
pmc: PMC8589683
doi:

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

4919-4930

Subventions

Organisme : NIMH NIH HHS
ID : R01 MH100041
Pays : United States
Organisme : NIMH NIH HHS
ID : R37 MH100041
Pays : United States
Organisme : NIMH NIH HHS
ID : T32 MH018951
Pays : United States

Informations de copyright

© 2021. The Author(s).

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Auteurs

J Scott Steele (JS)

Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA, USA. jsteele@uams.edu.
Brain Imaging Research Center, Department of Psychiatry, University of Arkansas for Medical Sciences, Little Rock, AR, USA. jsteele@uams.edu.

Michele Bertocci (M)

Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA, USA.

Kristen Eckstrand (K)

Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA, USA.

Henry W Chase (HW)

Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA, USA.

Richelle Stiffler (R)

Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA, USA.

Haris Aslam (H)

Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA, USA.

Jeanette Lockovich (J)

Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA, USA.

Genna Bebko (G)

Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA, USA.

Mary L Phillips (ML)

Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA, USA.

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