Nuclear Deformation Lets Cells Gauge Their Physical Confinement.

Cell Line, Tumor Cell Movement Cell Nucleus Cytoplasm Proprioception

Journal

Developmental cell
ISSN: 1878-1551
Titre abrégé: Dev Cell
Pays: United States
ID NLM: 101120028

Informations de publication

Date de publication:
25 01 2021
Historique:
entrez: 26 1 2021
pubmed: 27 1 2021
medline: 10 4 2021
Statut: ppublish

Résumé

How cells sense their physical microenvironment remains incompletely understood. In two recent Science articles, Lomakin et al. (2020) and Venturini et al. (2020) demonstrate that progressive nuclear deformation associated with cellular confinement triggers intracellular events that promote cell contractility and migration, revealing the nucleus to serve as a central mechanosensor.

Identifiants

DOI: 10.1016/j.devcel.2021.01.002 PMID: 33497620
pubmed: 33497620
pii: S1534-5807(21)00033-2
doi: 10.1016/j.devcel.2021.01.002
pii:
doi:

Types de publication

Journal Article Comment

Langues

eng

Sous-ensembles de citation

IM

Pagination

156-158

Commentaires et corrections

Type : CommentOn
Type : CommentOn

Informations de copyright

Copyright © 2021 Elsevier Inc. All rights reserved.

Auteurs

Joseph T Long (JT)

Meinig School of Biomedical Engineering, Cornell University, Ithaca, NY 14853, USA; Weill Institute for Cell and Molecular Biology, Cornell University, Ithaca, NY 14853, USA.

Jan Lammerding (J)

Meinig School of Biomedical Engineering, Cornell University, Ithaca, NY 14853, USA; Weill Institute for Cell and Molecular Biology, Cornell University, Ithaca, NY 14853, USA. Electronic address: jan.lammerding@cornell.edu.

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Classifications MeSH

questionsmedicales.fr › Cellules › Cellules cultivées › Cellules cancéreuses en culture › Lignée cellulaire tumorale › Nuclear Deformation Lets Cells Gauge Their...
questionsmedicales.fr › Phénomènes physiologiques › Mouvement cellulaire › Nuclear Deformation Lets Cells Gauge Their...
questionsmedicales.fr › Cellules › Structures cellulaires › Espace intracellulaire › Cytoplasme › Structures cytoplasmiques › Organites › Noyau de la cellule › Nuclear Deformation Lets Cells Gauge Their...
questionsmedicales.fr › Cellules › Structures cellulaires › Espace intracellulaire › Cytoplasme › Nuclear Deformation Lets Cells Gauge Their...
questionsmedicales.fr › Phénomènes physiologiques de l'appareil locomoteur et du système nerveux › Phénomènes physiologiques du système nerveux › Sensation › Proprioception › Nuclear Deformation Lets Cells Gauge Their...