Sphingosine 1-phosphate signaling in uterine fibroids: implication in activin A pro-fibrotic effect.
Activins
/ metabolism
Adult
Anion Transport Proteins
/ genetics
Case-Control Studies
Cell Line, Tumor
Female
Fibrosis
Humans
Leiomyoma
/ genetics
Lysophospholipids
/ metabolism
Middle Aged
Phosphotransferases (Alcohol Group Acceptor)
/ genetics
Signal Transduction
Sphingosine
/ analogs & derivatives
Sphingosine-1-Phosphate Receptors
/ genetics
Uterine Neoplasms
/ genetics
Uterine fibroids
activin A
fibrosis
leiomyomas
sphingosine 1-phosphate
sphingosine 1-phosphate receptors
sphingosine kinase
Journal
Fertility and sterility
ISSN: 1556-5653
Titre abrégé: Fertil Steril
Pays: United States
ID NLM: 0372772
Informations de publication
Date de publication:
06 2021
06 2021
Historique:
received:
06
10
2020
revised:
15
12
2020
accepted:
22
12
2020
pubmed:
28
1
2021
medline:
24
8
2021
entrez:
27
1
2021
Statut:
ppublish
Résumé
To explore the link between sphingosine 1-phosphate (S1P) signaling and leiomyoma and the possible S1P cross-talk with the fibrotic effect of activin A. Case-control laboratory study. University institute and university hospital. Patients with uterine fibroids (n = 26). Tissue specimens of leiomyoma and normal myometrium were obtained from patients undergoing myomectomy or total hysterectomy. Expression of mRNA levels of the enzyme involved in S1P metabolism, S1P receptors, and S1P transporter Spns2 was evaluated in matched leiomyoma/myometrium specimens and cell populations. The effects of inhibition of S1P metabolism and signaling was evaluated on activin A-induced fibrotic action in leiomyoma cell lines. The expression of the enzymes responsible for S1P formation, sphingosine kinase (SK) 1 and 2, and S1P This study shows that S1P signaling is dysregulated in uterine fibroids and involved in activin A-induced fibrosis, opening new perspectives for uterine fibroid treatment.
Identifiants
pubmed: 33500141
pii: S0015-0282(20)32769-2
doi: 10.1016/j.fertnstert.2020.12.022
pii:
doi:
Substances chimiques
Anion Transport Proteins
0
Lysophospholipids
0
Sphingosine-1-Phosphate Receptors
0
Spns2 protein, human
0
activin A
0
Activins
104625-48-1
sphingosine 1-phosphate
26993-30-6
Phosphotransferases (Alcohol Group Acceptor)
EC 2.7.1.-
sphingosine kinase
EC 2.7.1.-
sphingosine kinase 2, human
EC 2.7.1.91
Sphingosine
NGZ37HRE42
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1576-1585Commentaires et corrections
Type : CommentIn
Informations de copyright
Copyright © 2020 American Society for Reproductive Medicine. Published by Elsevier Inc. All rights reserved.