Strategies to lower fibroblast growth factor 23 bioactivity.
CKD
FGF23
Klotho
chronic renal failure
mineral metabolism
Journal
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association
ISSN: 1460-2385
Titre abrégé: Nephrol Dial Transplant
Pays: England
ID NLM: 8706402
Informations de publication
Date de publication:
22 09 2022
22 09 2022
Historique:
received:
02
09
2020
pubmed:
28
1
2021
medline:
24
9
2022
entrez:
27
1
2021
Statut:
ppublish
Résumé
Fibroblast growth factor 23 (FGF23) is a circulating hormone derived from the bone whose release is controlled by many factors and exerts a multitude of systemic actions. There are congenital and acquired disorders of increased and decreased FGF23 levels. In chronic kidney disease (CKD), elevations of FGF23 levels can be 1000-fold above the upper physiological limit. It is still debated whether this high FGF23 in CKD is a biomarker or causally related to morbidity and mortality. Data from human association studies support pathogenicity, while experimental data are less robust. Knowledge of the biology and pathobiology of FGF23 has generated a plethora of means to reduce FGF23 bioactivity at many levels that will be useful for therapeutic translations. This article summarizes these approaches and addresses several critical questions that still need to be answered.
Identifiants
pubmed: 33502502
pii: 6121358
doi: 10.1093/ndt/gfab012
pmc: PMC9494132
doi:
Substances chimiques
Biomarkers
0
Hormones
0
Fibroblast Growth Factors
62031-54-3
Fibroblast Growth Factor-23
7Q7P4S7RRE
Glucuronidase
EC 3.2.1.31
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
1800-1807Subventions
Organisme : NIDDK NIH HHS
ID : P30 DK079328
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01 DK081423
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01 DK091392
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01 DK092461
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01 DK115703
Pays : United States
Informations de copyright
© The Author(s) 2021. Published by Oxford University Press on behalf of ERA-EDTA. All rights reserved.
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