Endemicity of OXA-23 and OXA-72 in clinical isolates of Acinetobacter baumannii from three neighbouring countries in Southeast Europe.
Acinetobacter baumannii
Bosnia and Herzegovina
Croatia
Endemic oxacillinase
Serbia
Journal
Journal of applied genetics
ISSN: 2190-3883
Titre abrégé: J Appl Genet
Pays: England
ID NLM: 9514582
Informations de publication
Date de publication:
May 2021
May 2021
Historique:
received:
14
09
2020
accepted:
11
01
2021
revised:
20
12
2020
pubmed:
28
1
2021
medline:
19
8
2021
entrez:
27
1
2021
Statut:
ppublish
Résumé
According to the World Health Organization, bacterium Acinetobacter baumannii is the first on the critical priority list of pathogens in urgent need for new antibiotics. The increasing resistance of A. baumannii to the last-line treatment options, including carbapenems, is a global problem. We report the molecular epidemiology of 12 carbapenem-resistant clinical isolates of A. baumannii collected from hospitalised patients in three neighbouring countries in Southeast Europe: Croatia, Serbia, and Bosnia and Herzegovina, giving an insight into the molecular characterisation and evolutionary history of the acquisition of resistance genes. Besides the blaOXA-23 gene, the endemic presence of OXA-72 oxacillinase of the same origin for more than a decade as the leading mechanism of carbapenem resistance in Southeast Europe was confirmed. To the best of our knowledge, this is the first paper that investigates and analyses the phylogenetic association of the most common mechanisms of resistance to carbapenems in clinical isolates of A. baumannii originating from three neighbouring countries in Southeast Europe.
Identifiants
pubmed: 33502723
doi: 10.1007/s13353-021-00612-9
pii: 10.1007/s13353-021-00612-9
doi:
Substances chimiques
Anti-Bacterial Agents
0
Bacterial Proteins
0
Carbapenems
0
beta-lactamase OXA-23
EC 3.5.2.-
OXA-72 carbapenemase, Acinetobacter baumannii
EC 3.5.2.6
beta-Lactamases
EC 3.5.2.6
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
353-359Références
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